Project Details
Description
DESCRIPTION: (Adapted from applicant's abstract) The applicant proposes to
compare the presence of JC virus DNA, detected by PCR, in six patient
groups. These groups include patients with AIDS-associated PML, patients
with PML without AIDS, HIV-positive patients without evidence of PML,
patients with inflammatory disorders of the nervous system without
HIV-related disease or PML, immunosuppressed patients without PML or
HIV-related disease, and other neurologic controls. The applicant
anticipates that these experiments will serve the broad, long-term
objective of determining whether the presence of JC viral DNA, as detected
by PCR in the cerebrospinal fluid (CSF) of patients, can be used as a
non-invasive marker for the diagnosis of PML.
compare the presence of JC virus DNA, detected by PCR, in six patient
groups. These groups include patients with AIDS-associated PML, patients
with PML without AIDS, HIV-positive patients without evidence of PML,
patients with inflammatory disorders of the nervous system without
HIV-related disease or PML, immunosuppressed patients without PML or
HIV-related disease, and other neurologic controls. The applicant
anticipates that these experiments will serve the broad, long-term
objective of determining whether the presence of JC viral DNA, as detected
by PCR in the cerebrospinal fluid (CSF) of patients, can be used as a
non-invasive marker for the diagnosis of PML.
| Status | Not started |
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