Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease

PROJECT NARRATIVE Young-onset Alzheimer’s disease occurs in individuals who experience symptoms before the age of 65 and lack a known mutation. Using advanced neuropathology and transcriptomics technology, we seek to investigate why younger individuals suffer more significant accumulation of tau in neurons and more commonly report non-memory symptoms. Our scientific team has combined one of the largest series of young-onset Alzheimer’s disease brains to study, which will be critical for our evaluation of why certain brain regions and specific cells are vulnerable to changes in Alzheimer’s disease.