Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease

Project: Research project

Project Details

Description

PROJECT NARRATIVE Young-onset Alzheimer’s disease occurs in individuals who experience symptoms before the age of 65 and lack a known mutation. Using advanced neuropathology and transcriptomics technology, we seek to investigate why younger individuals suffer more significant accumulation of tau in neurons and more commonly report non-memory symptoms. Our scientific team has combined one of the largest series of young-onset Alzheimer’s disease brains to study, which will be critical for our evaluation of why certain brain regions and specific cells are vulnerable to changes in Alzheimer’s disease.
StatusActive
Effective start/end date2/15/2211/30/22

Funding

  • National Institute on Aging: $3,067,743.00

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