Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease

Project: Research project

Project Details


PROJECT NARRATIVE Young-onset Alzheimer’s disease occurs in individuals who experience symptoms before the age of 65 and lack a known mutation. Using advanced neuropathology and transcriptomics technology, we seek to investigate why younger individuals suffer more significant accumulation of tau in neurons and more commonly report non-memory symptoms. Our scientific team has combined one of the largest series of young-onset Alzheimer’s disease brains to study, which will be critical for our evaluation of why certain brain regions and specific cells are vulnerable to changes in Alzheimer’s disease.
Effective start/end date2/15/2211/30/22


  • National Institute on Aging: $3,067,743.00


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