Project: Research project

Project Details


DESCRIPTION: (Adapted from the applicant's abstract) Dr. David Smith
requests funds to support the Fifth International Chromosome 3
Conference to be held May 12-13, 1994 at the University of Michigan.
This meeting will bring together 40 researchers from throughout the
world who are committed to the construction of either genetic linkage
or physical maps for chromosome 3. The purpose of this workshop will
be to consolidate data generated by these laboratories to construct
high-resolution genetic linkage and physical maps for chromosome 3. To
ensure that consensus maps are derived from this meeting, the
participants will have to submit their data in advance as a requirement
for acceptance to the workshop. The structure of the meeting will be a
series of short presentations by each of the laboratories involved
followed by intense working sessions to resolve inconsistencies in the
map and to produce consensus maps. A major problem previously faced by
the chromosome 3 community has been that each group has been identifying
their own markers and constructing maps based upon them. Current plans
are to integrate the different markers into cohesive genetic linkage and
physical maps by exchanging markers between laboratories and using
commonly available reference libraries: (1) the total human Centre
d'Etude Polymorphisme Humain (CEPH) yeast artificial chromosome (YAC)
library; and (2) a recently constructed chromosome 3 cosmid library.
Various groups are currently isolating large YAC clones homologous to
their individual markers and by comparing YAC clones isolated by
different groups with their different markers it should be possible to
integrate all the markers into genetic linkage and physical maps of this
chromosome. This will also indicate areas of the chromosome that are
poorly characterized. The organizers will publish a report of this
meeting with consensus genetic linkage and physical maps within two
months of the date of the meeting.
StatusNot started


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