Insulin, the IGF Axis, and Colorectal Neoplasia

Project: Research project

Project Details

Description

DESCRIPTION (provided by applicant): The Cancer Prevention, Control, and
Population Sciences Career Development Award will provide an excellent
opportunity for me to acquire and refine the skills necessary to conduct
high-quality gastrointestinal cancer prevention research at a population
level. My proposed research plan involves the rigorous evaluation of a timely
central hypothesis with direct relevance to colorectal cancer prevention.
Using a series of different general, molecular, and genetic epidemiologic
approaches, I intend to explore unresolved or unexamined issues related to the
possibility that hyperinsulinemia, either alone or in combination with
insulin-like growth factor (IGF) axis proteins, is causally linked to
colorectal carcinogenesis. Existing data from cell culture experiments,
animal model systems, and human observational studies support this hypothesis,
yet many essential questions remain to be addressed. In the context of
mentored research, I plan to perform (1) a historical cohort study of type 2
diabetes mellitus (DM) and colorectal adenocarcinoma risk, (2) a case-control
study of type 2 DM and colorectal adenoma risk, (3) a nested case-control
study of serum insulin/IGF axis protein concentrations and colorectal
adenocarcinoma risk, (4) a pilot study of IGF axis mRNA expression levels in
neoplastic versus non-neoplastic colorectal mucosa, and (5) a prospective
cohort study of IGF axis gene polymorphisms among subjects with or without
colorectal neoplasia. These studies should provide meaningful scientific
data, while simultaneously affording me a broad exposure to and considerable
experience with several important investigational tools. To further enhance
my career development, I plan to obtain didactic training in areas relevant to
gastrointestinal cancer prevention research (including the responsible conduct
of research). Additionally, I intend to serve as an instructor for a cancer
epidemiology course at Mayo Graduate School. The resources of my sponsoring
institution are excellent and will facilitate the successful, efficient
completion of my overall objectives. Following achievement of these goals, I
am confident that I will be ready to continue my career as a successful
independent investigator committed to academic research.
StatusFinished
Effective start/end date7/1/016/30/06

ASJC

  • Medicine(all)