Immunity in healthy and neoplastic gut mucosa

Project: Research project

Description

DESCRIPTION (provided by the applicant): To develop and use an animal model for studying immune responses to antigen expressed in healthy and neoplastic intestine, addressing: 1) The role of thymus in tolerance of gut specific antigens and the generation of regulatory T cells (Treg), 2) The role of encounter of antigen in the periphery on the maturation and survival of Treg, 3) The immunologic consequences of delayed as compared with constitutive gut specific expression of antigen, 4) The influence of tumor growth on immune responses and tolerance.
StatusActive
Effective start/end date8/12/02 → …

Funding

  • National Institutes of Health: $54,352.00
  • National Institutes of Health: $56,308.00

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Immunity
Mucous Membrane
Antigens
Immune Tolerance
Histocompatibility Antigens Class II
Regulatory T-Lymphocytes
Thymus Gland
Intestines
Animal Models
Growth
Neoplasms