Project: Research project

Project Details


In the first three year period of this grant we have studied many
of the aspects of Magnetic Resonance (MR) image synthesis. This
has included optimization of the acquisition protocol, validation
of synthetic images, development of high speed instrumentation
for performing synthesis, and initiation of clinical studies. We
next propose first, to continue the technical and clinical
development of image synthesis, and second, to apply the
instrumentation to high speed MR image acquisition. The
individual parts of this proposal are:

1. MR Image Synthesis. Technical refinements will be made in
image acquisition and manipulation. A pulse sequence will
be developed enabling dual-TR multi-slice multi-echo
acquisition with respiratory compensation. This will
expedite the acquisition of MR images of the body.
Weighted linear image combination will be studied as a
means for maximizing contrast-to-noise (CNR) from a set of
acquired images. Modifications of this method will enable
selective material cancellation. Image synthesis will be
evaluated in specific clinical applications of meningioma,
liver, carcinoma of the bladder, and tumor and infection of
the bone marrow. Synthesis will be used to predict
optimized pulse sequences.
2. Imaging Instrumentation. Techniques developed for high
speed image synthesis will be applied to high speed realtime
image reconstruction. This will be applicable to recent
acquisition schemes which enable scan times of 2-10
seconds. The technique of "MR Fluoroscopy" will be
developed in which modestly degraded images will be
displayed in realtime during acquisition at 2 image/second
rates. In later years the instrumentation will be further
developed and applied to quasi-realtime MR angiography and
three-dimensional Fourier transform acquisition techniques.
Effective start/end date8/1/8412/14/04


  • Medicine(all)