HIGH SPEED DIAGNOSTIC MR IMAGING OF THE ABDOMEN

Project: Research project

Description

We propose to further develop fast scan MR imaging and real-time image
formation methods, as demonstrated in the previous grant cycle, for
improved visualization of abdominal cancer. The proposed end-point is a
single, integrated pulse sequence enabling completion of an MR abdominal
exam in 12 minutes. We hypothesize that diagnostic quality Tl- and T2-
weighted images superior in quality to conventional spin-echo images can
be efficiently acquired-using breath hold scan times. Work will be done on
three major projects: 1. Diagnostic Abdominal MR Image Acquisition. Diagnostic quality Tl-
weighted and T2-weighted MR images will be acquired within breath hold
scan times. Interleaved echo-planar and fast spin-echo methods will be
used to form-high quality T2-weighted images. 2DFT magnetization-prepared
gradient echo imaging will be refined to eliminate artifacts. Breath -hold
feedback techniques will be used to provide precise registration of
scanned sections from one acquisition to the next. Acquisition methods
will be developed for imaging contiguous sections during successive
registered breath-holds. 2. Interactive MR Imaging Techniques. The technique of breath-hold
feedback will be developed and refined to enable reproducible (S/I
diaphragmatic position within +/-1 mm) breathhold positioning. Methods
will be developed for high speed positioning and calibration. 3. High Speed Image Reconstruction. The acquired diagnostic Tl- and T2-
weighted images will be reconstructed immediately after acquisition with
high speed hardware. Modifications will be made to accommodate the
increased data rate and nonuniform response of multiple receiver coils.
High speed image projection techniques will be developed to aid in the
visualization of anatomy, pathology, and vasculature. 4. Integrated Pulse Sequence. The techniques developed in Projects 1, 2,
and 3 will be integrated into a single sequence such that the complete
exam time necessary to position the patient, perform calibration, and
acquire and reconstruct high quality TI- and T2-weighted images of the
liver is less than 12 minutes. Such times will improve the efficiency of the MR examination. Much of the
proposed work addresses the deficiencies of modern MRI in breath hold
imaging: deficiencies in the pulse sequences themselves, in accurate
measurement and positioning of the degree of breath-holding, in rapid
switching between sequences, and in image reconstruction.
StatusFinished
Effective start/end date8/1/8412/14/04

Funding

  • National Institutes of Health: $270,637.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $264,849.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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fluoroscopy
Computer-Assisted Image Processing
magnetic resonance
Diagnostic Imaging
Fluoroscopy
Abdomen
Magnetic Resonance Spectroscopy
Organized Financing
Artifacts
Calibration
Blood Vessels
spatial resolution
Angiography
Breath Holding
acquisition
Magnetic Resonance Angiography
Body Image
Kidney
Meningioma
Fourier Analysis

ASJC

  • Medicine(all)