HETEROGENEITY OF MYOCARDIAL PERFUSION &SOLUTE TRANSFER

  • Ritman, Erik L (PI)

Project: Research project

Project Details

Description

The overall goal of this proposal is to develop, evaluate, and utilize x-
ray CT derived indicator dilution curves to quantitate the physiologic
supply side of myocardial function in terms of the three-dimensional
distribution of intramyocardial blood volume, perfusion, and permeability-
surface area product. Each of five goal addresses one aspect of myocardial
perfusion by means of a sequential development, evaluation and application
phase. Much of the development of the basic image analysis techniques has
already been accomplished, either by ourselves or by other investigators,
hence this proposal addresses primarily development of mathematical models
needed to compute the physiological parameters. In this proposal we will
use the Dynamic Spatial Reconstructor (DSR), a volume imaging, fast CT
scanner, to study experimental animals and radiologic phantoms.
In AIM I we propose to show that the CT indicator dilution curves
correspond directly to the indices of solute transport estimated using
traditional, more invasive, methods. In AIM II we propose to show that intramyocardial blood volume, estimated
by fast CT, can be used to test hypotheses as to the relative importance of
microvascular recruitment, and the relationship of capillary permeability-
surface area product to flow. In AIM III CT estimates of myocardial perfusion will be used to quantitate
the functional significance of a coronary stenosis and the myocardial
volume at risk of infarction. In AIM IV a method for quantitating permeability-surface area product will
be developed and used in assessing the effects of myocardial ischemia and
edema. In AIM V the transfer function of the myocardial vascular bed will be used
to enable replacement of aortic root injections with central venous
injections. The significance of this work is that these studies should go a long way
towards developing a technique that is needed to answer important clinical
questions about the functional significance of a coronary artery stenosis
and important physiological questions about the relationship between
myocardial flow and solute transfer. These same techniques should be
almost directly applicable to other organs. As the DSR scanner's 3D images
can be mathematically reprojected, we can also use these 3D image data to
demonstrate the limits of the validity of these techniques (developed for
3D) in the more widely accessible 2D angiographic data. These developments
will, most likely, be almost directly applicable to other fast CT (e.g.,
Imatron) and in part to radionuclide emission and MRI images.
StatusFinished
Effective start/end date1/1/911/31/02

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $264,273.00
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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