Harnessing non-glucose feedback signals for automatic glucose control in type 1 diabetes: confronting exercise-safety and stress-aware control

Project: Research project

Project Details


Closed Loop or Artificial Pancreas (AP) systems are have been in clinical practice in early version since 2013 with a more advanced hybrid version becoming available in 2017. However, the current generation of these systems have several limitations (i) meal related glucose control is less than optimal (ii) physical activity and exercise may be associated with hypoglycemia thus limiting safety and efficacy and (iii) emotional stress is not accounted for and may limit efficacy. Solutions to these limitations may include (i) additional non glucose signals that could be used to modulate insulin delivery (ii) infusion/administration of additional agents/hormones such as glucagon and pramlintide or (iii) both. Our consortium has worked together to conduct novel outpatient AP studies. The consortium includes 2 clinical sites/investigators focused on T1D and a strong engineering group with versatile AP capabilities. We have also explored additional signals especially related to physical activity. In this application, we will assess the weaknesses of our most advanced AP during an eight week outpatient clinical trial. We will record physical activity signals throughout the eight weeks. We will also assess emotional stress using multiple modalities: a device, self report and salivary cortisol during week 1 and 5 of the AP trial. Our work will identify areas where analysis of physical activity and emotional stress signals can be used to advance AP development.

Effective start/end date8/1/177/31/19


  • Juvenile Diabetes Research Foundation United States of America: $771,766.00


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.