EHR-based Genomic Discovery and Implementation

PROJECT NARRATIVE The goal of our project is to combine validated polygenic risk scores (PRS) with conventional risk factors and family history to calculate comprehensive risk profiles for 15 common diseases that pose a significant public health burden. We will return risk estimates to 2500 participants (35% non-whites, 200 adolescents) and those at the highest polygenic risk will see a health care provider to discuss risk reduction measures. We will assess clinical, cost/utilization and psychosocial outcomes following return of results.