GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES

  • Turner, Stephen T (PI)
  • Kinney, Lea (PI)

Project: Research project

Project Details

Description

DESCRIPTION: (Adapted from Investigator's Abstract) Essential hypertension
is a common disorder that contributes to morbidity, mortality, and cost of
health care, especially among African-Americans. although diuretics are
commonly prescribed for treatment of hypertension, blood pressure decreases
in response to diuretic therapy in some individuals but not in others. The
proposed research will determine whether measured variation in genes coding
for components of the renin-angiotensin-aldosterone (RAA) system predicts
interindividual differences in blood pressure response to diuretic therapy
in 300 hypertensive African-Americans and in 300 hypertensive non-Hispanic
whites (total 600 individuals). The investigators will conduct a
standardized clinical protocol in which hypertensive adults are treated with
the diuretic
hydrochlorothiazide, 25 mg/day, for four weeks. They will measure
interindividual variation in five RAA system genes-- angiotensinogen, renin,
angiotensin-1 converting enzyme, angiotensin-II receptor, and aldosterone
synthase --to accomplish the following specific aims in each ethnic group.

Aim 1: To determine whether variation in genes of the RAA system predicts
interindividual differences in blood pressure response to diuretic therapy.

Aim 2: To determine whether variation in genes of the RAA system predicts
interindividual differences in baseline measures of the endocrine RAA system
or response of these measures to diuretic therapy.

Aim 3: To determine whether the predictive effects of variations in genes
of the RAA system on blood pressure response to diuretic therapy detected in
Aim 1 are mediated through their effects on baseline measures of the
endocrine RAA system or response of these measures to diuretic therapy,
detected in Aim 2.

Results of the proposed research have the potential to identify genes
contributing to the etiology of interindividual differences in blood
pressure response to diuretic therapy in African-Americans and in
non-Hispanic whites.
StatusFinished
Effective start/end date2/1/971/31/08

Funding

  • National Heart, Lung, and Blood Institute: $49,228.00
  • National Heart, Lung, and Blood Institute: $852,994.00
  • National Heart, Lung, and Blood Institute: $72,121.00
  • National Heart, Lung, and Blood Institute: $822,404.00
  • National Heart, Lung, and Blood Institute: $461,077.00
  • National Heart, Lung, and Blood Institute: $911,482.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $807,840.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $832,956.00
  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute: $667,564.00

ASJC

  • Medicine(all)

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