GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS

Project: Research project

Project Details

Description

This Network proposes to carry out five specific aims to localize and
characterize the genetic determinant of high BP. Aim 1 will use robust
sibling pair linkage methods in 500 hypertensive sibling pairs in each
racial group (a total of 1500 sibling pairs) to localize genes influencing
interindividual differences in the occurrence of EHYT. Aims 2 and 3 will
take advantage of previously collected BP and intermediate predictor trait
data rom 1488 sibling pairs from the Rochester (MN) Family Heart Study to
localize genes contributing to BP and EHYT. The proposed linkage analyses
(Aims 1-3) will use both an extensive array of candidate genes and a large
number of anonymous markers throughout the genome. Aim 4 will use multiple
diallelic sequence polymorphisms and cladistic analyses within a linked
gene to identify haplotypes for further DNA sequencing in order to
identify candidate functional DNA sequence variation contributing to
interindividual differences in BP level and EHYT status. Aim 5 will
evaluate the ability of candidate functional DNA sequence variation to
predict EHYT status in the three racial groups.
StatusFinished
Effective start/end date9/5/956/30/06

ASJC

  • Medicine(all)