GENETIC ANALYSIS OF ALOPECIA AREATA

Project: Research project

Project Details

Description

Alopecia Areata, patchy hair loss which may progress to total scalp or
body hair loss, affects 1-2 percent of the population. We hypothesize
that Alopecia Areata is an HLA (histocompatibility locus antigens)
restricted, T cell mediated autoimmune reaction to hair follicle
antigens or viral infection resulting from the interactions of multiple
genes of immune response which may result in the production of specific
antibodies to the hair follicle. Alopecia Areata occurs with other
autoimmune diseases, in identical twins and in families. It is
associated with HLA alleles and with other immune related genes that may
interact to determine susceptibility, resistance, and persistence.
Possible viral infection and antibodies to hair follicle, melanocytes,
keratinocytes, and endothelial cells are of unknown significance. Our
goal is to investigate the genetic mechanism of Alopecia Areata in
families of the purpose of disease prevention, early intervention, and
development of specific therapies. We propose: a) to identify and
collect DNA from AA families; b) to determine the genetic models for
Alopecia Areata by using the simultaneous information on both the
aggregation and association of the HLA marker with the disease and also
on the risk of being affected for some relatives of a patient; c) to
identify disease-predisposing amino acids in the HLA region involved in
the Alopecia Areata process; d) to identify polymorphic markers for
genetic loci that are associated with Alopecia Areata in families. To
accomplish aim a we will collect families from several dermatology
clinics in Houston. For aims b and c we will apply MASC and haplotype
methods. For aim d, we will use parametric and nonparametric linkage
methods.
StatusFinished
Effective start/end date9/30/988/31/02

ASJC

  • Medicine(all)