• Szurszewski, Joseph H (PI)

Project: Research project

Project Details


The broad objective of this proposal is to understand the physiological
processes which regulate the electrical and motor activity of canine and human
gastrointestinal smooth muscle. Smooth muscle of the canine gastric sling,
fundus, antrum, pylorus, muscularis mucosa, colon and human smooth muscle from
normal and diseased stomach and colon will be used. The areas of particular
interest are: (1) the voltage-tension relationship which defines the
electromechanical coupling characteristics; (2) pattern of intramural motor
nerve innervation; (3) the dose-response relationship in single smooth muscle
cells for gut peptides (gastrin, cholecystokinin, motilin, somatostatin,
substance P, vasoactive intestinal polypeptide and neurotensin) which act
directly on the smooth muscle cell and for these which have a neuromodulatory
action; (4) the identity of the nonadrenergic, noncholinergic inhibitory
transmitter in the muscularis mucosa; and (5) the electrophysiological events
responsible for or associated with disturbances in human gastric and colonic
motility. The in vitro methods of approach will be the simultaneous measurement
of intracellular electrical activity of single smooth muscle cells and motor
activity of the muscle, measurement only of motor activity of strips of muscle
and radioimmunoassay techniques for identification of the inhibitory transmitter
in the muscularis mucosa.
Effective start/end date12/1/7611/30/85


  • National Institutes of Health


  • Medicine(all)

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