FUNDAMENTAL STUDIES ON ALZHEIMERS DISEASE

  • Dickson, Dennis W (PI)
  • Kress, Yvonne (PI)
  • Shafit-Zagardo, Bridget (PI)
  • Vincent, Inez (PI)
  • Davies, Peter (PI)
  • Goldman, James (PI)
  • Ksiezak-Reding, Hanna (PI)
  • Shafit-Zagardo, Bridget (PI)
  • Vincent, Inez (PI)
  • Davies, Peter (PI)
  • Davies, Peter (PI)

Project: Research project

Project Details

Description

This is a renewal of additional studies of fundamental aspects of the
neurobiology of Alzheimer's Disease. In Project I, will continue studies
of the biochemistry and molecular biology of A68, the antigen recognized by
the monoclonal antibody Alz-50. The antigen has been purified to
homogeneity and sequencing studies are in progress. The purified antigen
appears to contain a protein kinase activity. In Project II, will continue
to investigate the nature of cDNA probes obtained using antibodies
recognizing neurofibrillary tangles. A cDNA encoding a portion of the MAP2
sequence has been identified to contain the binding site for the regulatory
subunit of the cyclic AMP dependent protein kinase. Possible abnormalities
in the concentration of the regulatory subunit will be investigated.
Interactions of proteins encoded by these and other cDNA's with other
cellular proteins will be investigated. In Project III, Drs. Dickson,
Mattiace and Yen will continue and extend their studies of senile plaque
formation, extending studies of human brain by examination of microglial
cells in tissue culture and studies of neuritic abnormalities in rat brain. A new project has been added, Dr. Hanna Ksiezak-Reding will investigate the
involvement of posttranslational modifications of tau protein in tangle
formation and neuritic abnormalities in Alzheimer's Disease. The possible
role of alternate splice variants of tau will also be investigated in
Alzheimer's Disease, and in brain development.
StatusFinished
Effective start/end date8/1/874/30/00

ASJC

  • Medicine(all)