FFA METABOLISM IN DIFFERENT TYPES OF HUMAN OBESITY

Project: Research project

Project Details

Description

The overall objective of this research proposal is to systemically
evaluate the differences in free fatty acid (FFA) metabolism
among obese persons with different body fat distributions, and
non-obese persons. By using rigorous anthropomorphic criteria to
characterize moderately overweight women as upper body or
lower body obesity, I have been able to discern distinct
differences in FFA metabolism between these two types of
obesity and non-obese women. Specifically, I have found that a)
FFA flux is normal in lower body obesity, but significantly
increased in upper body obesity; b) resistance to the ability of
insulin to suppress FFA flux and oxidation is present in both types
of obese women; and c) epinephrine results in a subnormal
lipolytic response in upper body obese women. These differences
may be due to localized, as opposed to generalized, abnormalities
in the regulation of adipose tissue depots. This proposal is
designed to test the following two general, but related
hypotheses: 1) regional differences in adipose tissue lipolysis are
present in vivo which account for the variations in resting
systemic FFA Flux observed among obese women with different
body fat topography, and 2) these differences in regional fat
accumulation are associated with different abnormalities of
suppression and stimulation of lipolysis. The specific aims of this
proposal are: 1) To determine if contribution of peripheral adipose
tissue to systemic lipolysis is less in upper body obese women than
lower body obese and non-obese women; 2) To test whether
regional variations in the ability of insulin to suppress lipolysis
exist in obese and non obese women; 3) To learn if the increased
FFA flux in upper body obesity is due to increased splanchnic
release of FFA; 4) To determine whether the suppressibility of
endogenous FFA and oxidation is impaired in upper body obese
women during meal absorption; 5) To learn whether decreased
sensitivity, decreased responsiveness, or both, is responsible for
the insulin resistance with regards to suppression of FFA Flux and
oxidation in upper body obese and lower body obese women: 6) To
determine if the decreased lipolytic response to epinephrine seen
in upper body obese women is due to decreased sensitivity or
decreased responsiveness to epinephrine: 7) To examine whether
the defect in the ability of upper body obese women to enhance
lipolysis extends to exercise, a physiologic circumstance in which
increased FFA availability is essential for optimal metabolic
function.
StatusFinished
Effective start/end date8/1/884/30/18

Funding

  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases: $453,506.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $434,165.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $357,319.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $267,570.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $494,083.00
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases: $378,933.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $377,892.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $367,958.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $494,083.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $536,485.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $273,351.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $536,485.00
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases: $379,253.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $444,909.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $446,909.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $494,083.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $279,305.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $480,415.00
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Diabetes and Digestive and Kidney Diseases: $446,851.00

ASJC

  • Medicine(all)

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