Exploiting new approaches for selective inhibition of trypsins

PROJECT NARRATIVE Trypsins are proteins that mediate disease processes in cancer and pancreatitis. More selective inhibitors are needed to target trypsins in order to study the roles of these proteins in diseases and as a stepping stone to developing better drugs to treat these diseases. In this project, we will develop highly selective trypsin inhibitors, along with innovative new methods for studying interactions between proteins that will be applicable to unraveling many disease processes and developing new drugs.