Esophageal Cancer from Cells to Population: A Multiscale Approach

  • Luebeck, Georg E. (PI)
  • Chin, Hur (PI)
  • Luebeck, Georg E. (PI)
  • Inadomi, John Matthew (PI)
  • Wang, Kenneth Ke Ning (CoPI)

Project: Research project

Description

PROJECT SUMMARY/ABSTRACT
Esophageal Cancer from Cells to Population: A Multiscale Approach
The goal of the proposed research is to reduce the burden of esophageal adenocarcinoma (EAC) by
optimizing surveillance of patients with Barrett's esophagus (BE) using cutting-edge endoscopic imaging and
advanced epigenetic profiling of neoplastic tissues in combination with standard endoscopic techniques. To
accomplish this goal we will establish a multidisciplinary collaboration between cancer biologists,
epidemiologists, clinicians and computational and mathematical modelers. This research team will develop a
multiscale modeling framework that synthesizes and integrates data generated from diverse sources and at
different scales to provide a coherent and informative portrayal of the natural history of EAC.
Simulation models of EAC actively supported by the NCI's CISNET (U01 CA152926) and data from the
Barrett's Esophagus Translational Research Network (BETRNet, U54 CA163060) will serve as the foundation
for a new biologically-motivated Multiscale Esophageal Adenocarcinoma Model (MEMo). This new model will
be informed by data that span numerous scales including: molecular level DNA methylation data, cellular level
volumetric laser endomicroscopy (VLE) data, patient level endoscopic surveillance data, and population level
cancer registry SEER data. We will use MEMo as an analytic tool to assess the clinical effectiveness of BE
surveillance protocols for early esophageal neoplasia detection and prevention. By the end of the award
period, we will have an improved and more comprehensive understanding of the biological and natural history
of EAC that provides a platform to design better strategies to control its population burden.
StatusFinished
Effective start/end date9/17/138/31/18

Funding

  • National Institutes of Health: $630,302.00
  • National Institutes of Health: $665,400.00
  • National Institutes of Health: $648,084.00
  • National Institutes of Health: $721,478.00

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Esophageal Neoplasms
Adenocarcinoma
Barrett Esophagus
Population
Natural History
Population Surveillance
Neoplasms
Translational Medical Research
DNA Methylation
Research
Epigenomics
Registries
Lasers

ASJC

  • Medicine(all)