Epigenetic dysregulation in diabetic enteric neuropathy

Project: Research project

Project Details

Description

Gastroparesis in patients with diabetes mellitus lacks curative therapy and represents a significant health care burden. Reduced expression of the enzyme producing the inhibitory neurotransmitter nitric oxide in gastric neurons is a pathogenetically significant alteration in gastroparesis, but pharmacological modulation of nitric oxide signaling has not been beneficial due to side effects. This project will determine how impaired mitochondrial metabolism in diabetes and consequent dysregulation of gene transcription can be reversed to restore nitric oxide-dependent gastric functions using drugs already approved for use in humans.
StatusActive
Effective start/end date1/1/2112/31/22

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $525,692.00

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