Project: Research project

Project Details


A unique set of circumstances access to the resources of Independent
School District #535 Student Support Services (which provides evaluation
and management for the children from all public, parochial, and private
schools in Rochester), of the privately owned Rochester Reading Center
(which includes a pool of some 3,000 evaluations and outcomes of tutorial
instruction that span nearly 50 years), and of the established Rochester
Epidemiology Project (a richly-documented medical records-linkage system
located at Mayo Clinic) -- will enable us to conduct a number of studies
to further our knowledge of learning disabilities (LD) in a delineated
population. For this study, LD will include dyslexia and problems
related to writing, reasoning, and mathematics. These entities have long
been recognized for their significant social, educational, and medical
import. This study will produce estimates of the incidence of LD among
a birth cohort of children, born 1976-1980 in Rochester, Minnesota, as
well as to determine the prevalence of LD on August 1, 1992. Further,
a nested case-control study will assess the association between factors
from birth certificates and medical records, as well as a parent
questionnaire, with risk of developing LD. We will estimate the amount
of familial aggregation of LD and we will determine the genetic and non-
genetic components that influenced any observed familial aggregation.
Also, complex segregation analysis will be conducted with learning
disabled incident cases as probands. We will assess the potential impact
of referral biases inherent in referral-based studies of LD by comparing
the population-based incident learning disabled cases with learning
disabled cases (born during the same period of time) from the Mayo
referral practice. Finally, the current status of incident cases, 1976-
1980, and their matched controls will be assessed using a group of
standard psychological tests for each student to better understand the
long-term outcomes of children with LD. Thus, at the conclusion of this
study, we will have advanced our knowledge of the occurrence of LD, and
provided new information about the etiology and familial aggregation of
LD and further insight of the natural history/clinical course of the
Effective start/end date8/15/957/31/99


  • Medicine(all)