ENTEROBACTERIA IN HLA-B27 LINKED SPONDYLOARTHROPATHIES

  • David, Chella S (PI)

Project: Research project

Project Details

Description

The seronegative spondyloarthropathies are a group of inflammatory
diseases in which the spine, peripheral joints, skin, eyes, and other
tissues of the body may be involved. There are many common clinical,
radiological and pathological features. The observation of the strong
association of HLA-B27 antigen (60-90% compared to 8% in the normal
population) has further strengthened the commonality among these
diseases. The development of Reiter's syndrome and reactive arthritis in B27
positive individuals occurs after gastrointestinal infection with one of
several species of bacteria, including Yersinia, Salmonella, Shigella,
Campylobacter, and Chlamydia. In addition, the work from several
laboratories suggest that Klebsiella pneumoniae may play a role in the
pathogenesis of ankylosing spondylitis in B27 positive individuals. The
mechanisms by which intestinal microbes react with B27 to induce
arthritic disease is not known, however, several theories have been
postulated. For instance, there may be crossreactivity between HLA-B27
gene have already been developed in our laboratory for this purpose. With
these mice, we would like to 1) induce arthritic disease by immunization
with intestinal bacteria; and 2) determine which aspect of the
interaction between HLA-B27 and bacterial infection is responsible for
inducing reactive arthritis. In addition, background and major
histocompatibility genes in mice can be easily manipulated so that we can
determine whether another gene in linkage disequilibrium with HLA-B27 is
necessary for the production of arthritic disease. Determination of the
components responsible for the promotion of disease will open several
doors to immune intervention and immunotherapy.
StatusFinished
Effective start/end date3/1/891/31/03

Funding

  • National Institutes of Health: $127,113.00
  • National Institutes of Health
  • National Institutes of Health: $195,701.00
  • National Institutes of Health: $114,292.00
  • National Institutes of Health
  • National Institutes of Health: $219,846.00
  • National Institutes of Health: $207,617.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $213,846.00

ASJC

  • Medicine(all)

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