Engineering tissue inhibitor of metalloproteinases-2 (TIMP-2) for triple negative breast cancer therapy

Project: Research project

Project Details


PROJECT NARRATIVE “Triple negative” breast cancer (TNBC) is a subtype of breast cancer that spreads aggressively and often leads to metastasis and death; it is difficult to treat because it does not respond to current molecularly-targeted drugs. TIMP2 is a natural human protein with two anticancer activities: (1) it inhibits an enzyme involved in TNBC metastasis, and (2) it binds to a cell surface receptor to inhibit TNBC growth. We propose to develop a new cancer drug, based on TIMP2, with improved capability to inhibit both metastasis and tumor growth, providing a new therapy to improve survival for patients with TNBC.
Effective start/end date3/1/212/28/23


  • National Cancer Institute: $290,242.00
  • National Cancer Institute: $336,617.00


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