Engineering selective inhibition of metalloproteinases by tissue inhibitors of metalloproteinases (R01 GM132100 RESUB - *TIMPs)

Project: Research project

Project Details


PROJECT NARRATIVE Matrix metalloproteinases (MMPs) are enzymes that mediate many disease processes in cancer, cardiovascular disease, autoimmune disease, and other diseases. Drugs that inhibit MMPs have been largely unsuccessful because they target the entire MMP family, which includes both helpful and harmful enzymes. In this project, we will develop methods and tools that can be used to identify the most harmful MMPs as drug targets, and to develop highly selective drugs to target these enzymes.
Effective start/end date4/1/2012/31/22


  • National Institute of General Medical Sciences: $313,000.00
  • National Institute of General Medical Sciences: $281,700.00


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