Elucidating the 3-D epigenetic determinants of activity-dependent gene expression in mammalian neurons

Project: Research project

Project Details

Description

Public Health Relevance/Narrative Brains have evolved to process and store information from the outside world and do so through synaptic connections among interconnected networks of neurons. Our work will illuminate higher-order genome folding as an unexplored dimension of the long-range epigenetic control governing neuronal activation in the mammalian brain. Synaptic defects underlie many neurological disorders, therefore understanding the molecular mechanisms governing activity-dependent expression is of tremendous importance toward our knowledge of how neural circuits are disrupted in brain disease.
StatusFinished
Effective start/end date2/1/2012/31/22

Funding

  • National Institute of Neurological Disorders and Stroke: $414,081.00
  • National Institute of Neurological Disorders and Stroke: $474,500.00
  • National Institute of Neurological Disorders and Stroke: $414,453.00

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