Project Narrative DNA-protein crosslinks (DPCs) are a serious threat to genome stability and have the potential to cause cancer if they are left unrepaired. The proposed study will investigate the mechanistic role of a putative protease in DPC repair and determine the consequence of its deficiency on tumor cell sensitivity to DPC-inducing chemotherapies, genome stability, and tumorigenesis in a mouse knockout model.
|Effective start/end date||1/1/19 → 12/31/22|
- National Cancer Institute: $327,341.00
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