DNA-Protein Crosslinks and Genomic Instability

Project: Research project

Project Details

Description

Project Narrative DNA-protein crosslinks (DPCs) are a serious threat to genome stability and have the potential to cause cancer if they are left unrepaired. The proposed study will investigate the mechanistic role of a putative protease in DPC repair and determine the consequence of its deficiency on tumor cell sensitivity to DPC-inducing chemotherapies, genome stability, and tumorigenesis in a mouse knockout model.
StatusActive
Effective start/end date1/1/1912/31/22

Funding

  • National Cancer Institute: $327,341.00

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