Description

The Administrative and Biostatistics Core will provide the overall leadership as well as the infrastructure for the
Program Project Grant (PPG). The 3 Projects in the PPG represent independent but highly interactive
proposals by experienced investigators who have a long track record of collaborative studies. A major goal of
the Core, therefore, is to ensure optimal interaction and integration among the Projects. These diverse
Projects also need the appropriate infrastructure and logistical support, such as sample acquisition and
storage, data management, and central administrative coordination. Finally, throughout the history of this
PPG, the Core has provided statistical support to the investigators and trainees associated with the Projects.
This is the only Core being requested in support of this PPG, owing in large part to the unique environment at
Mayo, where institutional Cores provide much of the needed scientific infrastructure. Thus, the Specific Aims
for the Core are 1) To provide the administrative leadership for the PPG;2) To provide the appropriate
infrastructure for the conduct of the studies;and 3) To provide the biostatistical and bioinfomatic resources
needed for the design and analysis of the studies. Aim 1 is accomplished through an internal Administrative
Committee that will meet on a regular basis as well as an external Advisory Committee that will meet by
teleconference annually and at least once in person during the funding cycle. Aim 2 is accomplished by a
dedicated sample processing and data management team, along with administrative support. Aim 3 relies on
the expertise of Dr. Therneau, Ms. Atkinson (a Masters level statistician who has had a long-term participation
in the PPG), and a data analyst. These individuals accomplish complex statistical functions and also provide
statistical advice and support to each of the investigators. Collectively, the Administrative and Biostatistics
Core is the underpinning of this highly successful endeavor. This is reflected, in part, by the unique ability of
our group to combine knowledge gained from population-based epidemiology studies, intensive human
investigation, animal studies, and basic bone biology. Moreover, the success of the infrastructure and
biostatistical support is perhaps best reflected by the ongoing productivity of our group, thus making the sum
clearly greater than the parts.
StatusNot started

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

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Bone and Bones
Osteoporosis
Osteogenesis
Estrogen Receptors
infrastructure
Heart Failure
Organized Financing
Osteocytes
Sympathetic Nervous System
Estrogen Receptor alpha
Bone Density
Population
Osteoblasts
leadership
statistician
Bone Remodeling
Skeleton
data acquisition
Standard of Care
epidemiology

ASJC

  • Medicine(all)