The purpose of this proposal is to evaluate the effect of an AW inhibitor of dihydropyrimidine dexydrogenase (DPD) 776C85 used concomitantly with low oral doses of 5-fluorouracil (5-FU). The study will examine the efficacy of a 28 day dose of the combined drugs on toxicity in a phase I setting in patients with colorectal cancer.
|Effective start/end date||10/1/95 → 9/30/97|
- National Center for Research Resources
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