CHRONIC LIVER DISEASES--SURVIVAL MODELS AND APPLICATION

  • Kim, W Ray (PI)
  • Dickson, E. (PI)
  • Dickson, E. (PI)

Project: Research project

Project Details

Description

Liver transplantation, although extremely demanding, has been shown to be
technically feasible and now offers an alternative therapeutic approach
which may prolong life in some patients suffering from severe chronic liver
disease. Very important questions remain regarding the selection of
patients who may benefit from liver transplantation and the stage of the
patient's liver disease at which transplantation should be performed. We
plan to address these issues by the development of statistical models.
These models will provide necessary information concerning the natural
history of the chronic liver diseases and will enable screening evaluations
of the efficacy of interventions such as liver transplantation. In this
proposal, we will be using a very comprehensive data base which involves
over 1,000 patients seen at this institution between 1974 and 1983 with
primary biliary cirrhosis, primary sclerosing cholangitis, and chronic
active hepatitis. These three major diagnostic categories of nonalcoholic
liver disease comprise the majority of adult liver transplantation
patients. A statistical modeling system will be developed to estimate
survival of these patients. It will be used first to assist in the
selection of patients during the initial phase of liver transplantation at
this institution. Second, the statistical model will provide necessary
control information in order to make screening evaluations of the efficacy
of liver transplantation. Third, in randomized controlled clinical trials
which will be designed to definitively assess the timing of liver
transplantation, the modeling system will provide information necessary to
identify patients in the "early-advanced stage" of their liver disease and
those in the "late-advanced stage." These studies, we hope, will
contribute to improve survival following liver transplantation. We are in
a unique position to carry out this proposal. First, we have a very large
volume of patients in whom a comprehensive data base of clinical,
biochemical, immunological, and histological data are available. Second,
we have statistical expertise and computer resources necessary for the
development of the appropriate statistical models. Finally, the clinical
and surgical expertise is present to provide care for these patients in
both the pre-transplantation and post-transplantation phase.
StatusFinished
Effective start/end date1/15/866/30/16

Funding

  • National Institutes of Health: $559,448.00
  • National Institutes of Health: $408,122.00
  • National Institutes of Health: $570,343.00
  • National Institutes of Health: $468,828.00
  • National Institutes of Health: $544,027.00
  • National Institutes of Health: $637,320.00
  • National Institutes of Health: $538,819.00
  • National Institutes of Health: $529,073.00
  • National Institutes of Health: $583,562.00
  • National Institutes of Health: $413,293.00
  • National Institutes of Health: $494,386.00

ASJC

  • Medicine(all)

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.