CENTER FOR CELLULAR &MOLECULAR STUDIES IN REPRODUCTION

  • Veldhuis, Johannes D (PI)
  • Desjardins, Claude (PI)
  • Haisenleder, Daniel J. (PI)
  • McCartney, Christopher R. (PI)
  • Nestler, John (PI)
  • Haisenleder, Daniel J. (PI)
  • Tung, Kenneth (PI)
  • Shupnik, Margaret (PI)
  • Marshall, John (PI)
  • Shupnik, Margaret (PI)
  • Levine, Jon (PI)
  • Moenter, Suzanne (PI)
  • Burt Solorzano, Christine Michele (PI)
  • Moenter, Suzanne (PI)
  • Haisenleder, Daniel J. (PI)
  • McCartney, Christopher R. (PI)
  • Shupnik, Margaret (PI)
  • Haisenleder, Daniel J. (PI)
  • McCartney, Christopher R. (PI)

Project: Research project

Project Details

Description

This application requests support for a core center to enhance cellular
and molecular studies in reproductive science at the University of
Virginia. The proposed P-30 Center will have a synergistic impact on
reproductive-related research. First, it will supplement the
institution's investment in faculty, staff, and space by providing
support for critical technical resources. These resources will
facilitate innovative studies of hormone action on reproductive cells and
the pathophysiology of infertility in animal models and humans. Second,
the P-30 Center will extend NIH's investment in R01 awards for
reproductive-related work by allowing us to improve efficiency and
quality control at significant cost savings. Third, P-30 and R01 awards
will be integrated under the framework of the Center for Research in
Reproduction to promote interaction between basic and clinical scientists
who have a compelling record of collaboration in both research and
training. together, these three elements will shape the quality and
productivity of basic and clinical research in fertility and infertility
at the University of Virginia. Four cores are proposed: administrative,
molecular biology, ligand preparation and assay, and cell science. The
cores will serve members of the Center for /Research in Reproduction
whose research focuses on: 1) the regulation of gene expression by cells
that limit or control gonadal function, 2) the autocrine, paracrine, and
endocrine regulation of specific cell types within the anterior
pituitary, ovary, and testis, and 3) the neuroendocrine mechanisms that
signal the onset of reproductive development in children or limit
reproductive performance in adults. Access to the core laboratories will
further enhance the productivity of both faculty and fellows who are
engaged in reproductive-related research by: 1) offering training in
molecular biology and cell science, 2) providing access to technical
procedures and instrumentation required for molecular studies,
preparation of ligands, hormone assay, and image processing for single
cells and tissues, and 3) promoting the development of new or improved
methods that must be in place to study clinically relevant aspects of
fertility and infertility in animal models and man. The P-30 Center will
reduce costs by centralizing technical procedures and thereby reducing
redundant equipment and personnel effort. Access to computer-assisted
technologies will simplify data acquisition, standardize routine
analytical procedures, and improve quality control. The special
attributes of a P-30 Center will allow us to catalyze interdisciplinary
approaches among basic and clinical scientists who have the background,
commitment, and resources to develop and fully explore innovative
questions about reproductive performance in healthy and diseased states.
StatusFinished
Effective start/end date4/1/933/31/19

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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