CD8+ HELPER INDEPENDENT T CELLS IN TUMOR THERAPY

Project: Research project

Project Details

Description

DESCRIPTION: The investigator proposes studies with L-selectin down regulated
CD8+ T cells in mice to see whether their effectiveness can be improved with
cytokines, examine the histology of tumors to see where administered CD8+ cells
traffic, whether they undergo apoptosis or become tolerated at the tumor site.
Dose-response studies with various numbers of T cells will also be performed
against established tumors. The use of dendritic cells with peptides will also
be explored to immunize the mice from which the T cells are obtained. Treatment
of the tumor with cyclooxygenase inhibitors will also be studied to see whether
tumor-induced suppression can be overcome.
StatusFinished
Effective start/end date1/1/019/30/08

ASJC

  • Medicine(all)