Causes and Consequences of Differences in Body Fat Distribution

Project: Research project

Project Details

Description

This Mentor-Based Postdoctoral Fellowship Award will support the training of a qualified Ph.D. in the field of metabolic research with respect to obesity, metabolic syndrome and type 2 diabetes. The research fellow will learn: 1) How to use unique, detectable fat molecules to measure how the body's fat cells take up and store fat; 2) How to use state-of-the-art instruments that can measure stable isotopes of fat-containing molecules; 3) The bench laboratory assays needed to measure fatty acid storage factors in fat cells collected from research volunteers; 4) How to perform adipose (and muscle) biopsies in a safe, supervised environment. The trainee will gain these skills in the context of conducting an NIH-funded study involving volunteers with various conditions that selectively affect different fatty acid storage proteins. Examples include men with low levels of male hormones (testosterone), who have high levels of some fat storage proteins in thigh fat, estrogen deficient women, who have high levels of a different fat storage protein in thigh fat, upper body obese women who have low levels of a third fat storage protein. The ability of fat cells to take up and store fat under conditions of high and low fat availability will be measured. This will help us understand the beneficial and potentially harmful ways that fat molecules can be handled by fat cells. It is anticipated that this fellowship will prepare a promising new Ph.D. as a successful independent investigator in the field of diabetes and metabolism.
StatusFinished
Effective start/end date7/1/126/30/16

Funding

  • American Diabetes Association

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