Catheter-Directed Thrombolytic Therapy: Deep Thrombosis

Project: Research project

Project Details


DESCRIPTION (provided by applicant):
The candidate?s long-term objective is to develop a career in the field of
clinical hemostasis and thrombosis research in an academic health center
environment. In this proposal, he will investigate strategies to prevent
postthrombotic syndrome (PTS), a common sequel of deep vein thrombosis (DVT).
The proposed career development plan incorporates a multi-faceted curriculum.
This includes structured didactic courses designed to augment his previous
Masters in Clinical Research curriculum, participation in clinical and
research seminars, and an intense, closely mentored, clinical research
experience. With the guidance of his sponsor, co-sponsor, and consultants, the
candidate will conduct a pilot study comprised of 30 subjects to evaluate the
feasibility of a subsequent multi-center, open label, randomized clinical
trial comparing thrombolytic therapy to standard anticoagulation in the
treatment of proximal DVT, with the primary goal of reducing the incidence of
PTS. The pilot study will be complemented by a retrospective analysis of data
gathered from a ten-year experience of catheter-directed thrombolytic therapy
at the University of Minnesota, specifically evaluating clot lysis rate, and
adverse events. He will also review the medical records of all the patients
diagnosed with DVT during the period 1997-2000, to estimate the proportion of
patients who would potentially be eligible for the clinical trial using the
proposed eligibility criteria of the pilot study. Finally, the candidate will
synthesize lessons learned from the retrospective analyses and the pilot
study, and under the guidance of his Advisory Committee, he will establish the
required research infrastructure to conduct the definitive clinical trial. The
proposed curriculum will help the candidate acquire technical and academic
skills required to become an independent clinical investigator. It will help
him foster a close link between the various faculty members participating in
the pilot study, and facilitate the formation of a network of investigators
with common interests, thus promoting collaborations for future studies.
StatusNot started


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