Project: Research project

Project Details


The goal of this proposal is to develop and investigate methods and
instruments for obtaining reliable quantitative ultrasound images of
several acoustic paramenters within two-dimensional coronal cross sections
of the breasts of women. The instrument and associated programs will
synergistically combine quantitative multimodal images to obtain diagnoses
of breast disease. Ultrasound computer-assisted transmission tomography
will be utilized to obtain quantitative images of acoustic speed, acoustic
attenuation, acoustic absorption and scatter and reflection where
appropriate. Both analytic and iterative methods of correcting aberrations
in the images caused by inhomogeneous refractive index will be
investigated. Compound B-scan images will also be obtained in the same
coronal planes. Our clinical scanner will be modified to obtain data
necessary for high fidelity images derived using newly developed inverse
scattering methods. Patients scheduled for surgical biopsy will be scanned
and the resulting images compared to the histology results from biopsy
and/or surgical mastectomy. Comparisons between surgical specimens and
acoustic images will be made using methods of automated computer-assisted
pattern classification and recognition combined with histological methods
of tissue preparation specifically designed to aid in comparing ultrasound
images of the coronal plane of the intact breast with similar planes
through the excised breast. This parallel investigation of the clinical
instrument, inverse scattering methods, histologic tissue analysis
techniques, and pattern recognition programs should result in complete
evaluation of the prototype clinical scanner and may result in an
instruemnt design capable for use in the clinical environment.
Effective start/end date1/1/7912/31/88


  • National Cancer Institute
  • National Cancer Institute
  • National Cancer Institute


  • Medicine(all)


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