• Melton, III, L Joseph III (PI)

Project: Research project

Project Details


This proposal utilizes the unique resources of Mayo Clinic and the
Rochester Epidemiology Program Project (REPP) to conduct a
retrospective incidence cohort study to assess breast cancer risk
among women with benign breast disease. By integrating the
histopathologic evaluation capabilities of Mayo Clinic and the
population-based epidemiologic data provided by the REPP, this
research will provide a detailed assessment of the risk of breast
cancer associated with specific histologically defined
subcategories of proliferative benign breast disease. The study
pathologist will collaborate with Dr. Page to ensure that the
Page-Dupont criteria are applied to the breast tissue pathologic
slides. Breast tissue from an estimated (9,000) women in the
Olmsted County community and at Mayo Clinic from 1/1/67-
1/1/83 will be evaluated histopathologically with these criteria,
and this retrospective incidence cohort will be followed for
occurrence of breast cancer to 1/1/88. Using breast cancer cases
and a matched control group from this cohort, a nested biopsy
from medical records of these patients. In addition, DNA flow
cytometry and immunohistochemistry will be conducted on benign
breast disease tissue from cases and controls. The combined
clinical, epidemiologic, flow cytometric, and histopathologic data
will be used to evaluate the interaction between these factors and
breast cancer risk. Previous REPP research concerned with the
relationship between benign breast lesions and subsequent breast
cancer affirms the ability of this data source to identify the
relevant study population. Ongoing participation in the DES-
breast cancer studies verifies the ability to determine the
appropriate clinical and epidemiologic parameters and to provide
nearly 100% follow-up for breast cancer occurrence to 1/1/88 in
this (9,000) member benign breast disease incidence cohort. More
than 300 cases of breast cancer are anticipated in this cohort
which should provide adequate power to detect clinically and
statistically important relationships of interest. Comparisons
between the Olmsted County cohort and the non-Olmsted County
Mayo Clinic referral cohort will provide a unique opportunity to
determine the influence of referral bias on the epidemiology of
benign breast disease. This study will, therefore, assess the
predictive validity of the Page-Dupont criteria and determine if
additional clinical, epidemiologic, flow cytometric, or
histopathologic factors improve the precision of risk assessment.
Effective start/end date9/30/878/31/90


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)


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