Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial

  • Khosla, Sundeep S (PI)
  • Rosen, Clifford C.J (CoPI)
  • Black, Dennis D.M (CoPI)
  • Shane, Elizabeth E.J (CoPI)
  • Khosla, Sundeep (CoPI)
  • Rosen, Clifford James (CoPI)
  • Shane, Elizabeth J. (CoPI)

Project: Research project

Project Details


Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Based on key preliminary findings, our proposal aims to translate evidence from rodent studies showing that the sympathetic nervous system is an important regulator of bone metabolism to a simple, cost- effective, and safe approach for osteoporosis prevention. Specifically, we will test whether a commonly used cardiovascular drug, atenolol, can prevent bone loss over 2 years in postmenopausal women.
Effective start/end date1/1/2112/31/22


  • National Institute on Aging: $2,347,808.00


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