Project Details
Description
PROJECT NARRATIVE
Multiple myeloma (MM) is an incurable cancer of plasma cells that is always preceded by an asymptomatic
phase comprised of pre-cancerous plasma cells such as in monoclonal gammopathy of undetermined
significance (MGUS), or smoldering multiple myeloma (SMM). Given the incurable nature of MM, this project
aims to measure the levels of select metabolites in the bone marrow plasma of patients with a spectrum of
plasma cell disorders via mass-spectrometry-based approaches so as to distinguish between pre-cancerous
and cancerous plasma cells. Ultimately, the knowledge gained from this study will help lower the risk of
morbidity and mortality in the general population who remain at risk of developing MM from entities with pre-
cancerous plasma cells such as MGUS and SMM; this study will also lay the basis of developing novel
strategies in the future to prevent this progression of pre-cancerous plasma cells to MM.
Status | Active |
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Effective start/end date | 3/1/21 → 2/28/23 |
Funding
- National Cancer Institute: $327,341.00
- National Cancer Institute: $363,713.00
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