ALZHEIMER'S DISEASE CENTER CORE GRANT

Project: Research project

Description

The proposed Mayo Clinic Alzheimer's Disease Research Center (ADRC) is
designed to be a major patient evaluation, research, and education
resource for the upper Midwest. Epidemiology studies utilizing the
population data base at the Mayo Clinic have provided the first age- and
sex-specific incidence rates in the United States for dementing illnesses.
The Mayo Clinic ADRC will extend these epidemiologic studies through a
prospective community survey to establish prevalence rates in the urban
and rural populations of Olmsted County, Minnesota. Case/control studies
have been designed to evaluate etiologic risk factors including familial
aggregation, environmental, and occupational toxic exposures. In the
course of the community survey, a large number of non-demented elderly
subjects will be identified, and normative values for commonly used
neuropsychological tests for the elderly and the very elderly (80 and
over) will be established. A unique feature of this ADRC is its ability
to compare a community based population with a referral population with
respect to demographic and clinical characteristics as well as
survivorship. A neuropharmacology research project will study muscarinic acetylcholine
receptor subtypes in Alzheimer's disease. A neuroimaging project will
correlate volumetric changes in medial temporal lobe structures as
measured by magnetic resonance imaging and functional changes as measured
by single photon emission computed tomography with neuropsychological,
clinical, and demographic characteristics of Alzheimer's disease patients
and normal controls in a longitudinal fashion. The primary focus of the proposed ADRC in the initial years will be to
establish a regional referral center for patients with Alzheimer's
disease. The Mayo clinic is expanding its commitment to alzheimer's
disease research by establishing an Alzheimer's disease research facility
as part of its Jacksonville, Florida, clinic. It is anticipated that the
proposed ADRC will expand to encompass the Jacksonville activities in
future years.
StatusFinished
Effective start/end date9/15/904/30/00

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Alzheimer Disease
Research
Organized Financing
Caregivers
Education
Guam
Advisory Committees
Autopsy
Information Dissemination
Transfer (Psychology)
Referral and Consultation
Dementia
Demography
Neuroimaging
Epidemiology
Magnetic Resonance Imaging
Physicians
Population
Neuropharmacology
Poverty

ASJC

  • Medicine(all)