Project: Research project

Project Details


The Mayo Alzheimer's Disease Center (ADC) was funded in 1990 as an
Alzheimer's Disease Core Center. As such, it initially had the four
required cores; Administrative, Clinical and Research Support,
neuropathology, and Research Training and Information Transfer. It has
subsequently added two satellite projects. The major scientific themes of
the Center involve the epidemiology of Alzheimer's disease (AD) and the
clinical, imaging and neuropathological evaluation of the boundary between
normal aging and early AD.

The administrative structure for the Center has dealt with the pilot
project review process, the External Advisory Committee, and budgetary and
personnel issues. The Clinical Core has developed a standardized
mechanism for recruiting, evaluating and triaging patients from community
and referral sources. The Neuropathology Core has provided neuropathologic
diagnoses on cases of AD and normal controls and has processed and
distributed biological tissue to other investigators. The Information
Transfer Core has been active in promoting educational activities for
professionals, paraprofessionals, patients and caregivers. A satellite in
Jacksonville, Florida has been successful at recruiting minority and
indigent patients as well as developing an autopsy program. A unique
satellite project involving the clinical and laboratory evaluation of
patients with neurodegenerative diseases an normal controls from Guam is

In the proposed grant period we plan to continue with the four basic cores
with minor modifications in their scope and function. We will also
continue the satellite in Jacksonville, Florida. The satellite involving
the patients and controls from Guam was designed only for the years 03-05
of the initial grant period and will be discontinued. We have proposed the
addition of a Neuroimaging Core in this application to develop new
techniques in magnetic resonance imaging to further the scientific themes
of the ADC. The Mayo ADC has been productive in its initial years and this
proposal represents its plan for continued growth in promoting research in
StatusNot started


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