Airway Structural Cells and Corticosteroid Resistance in Asthma

NARRATIVE It remains difficult to effectively alleviate asthmatic symptoms and limit disease progression in children with severe asthma. While corticosteroids can be effective, children with severe asthma develop corticosteroid insensitivity or resistance making their disease difficult to manage. The goal of this proposal is to understand how inflammation promotes corticosteroid resistance in the context of severe pediatric asthma. These studies are also aimed to assess the potential for therapeutic strategies to improve corticosteroid sensitivity.