• Poeschla, Eric M (PI)
  • Pond, Sergei L. Kosakovsky (PI)
  • Grant, Igor (PI)
  • Mathews, W. (PI)
  • Bozzette, Samuel (PI)
  • Spector, Stephen (PI)
  • Kornbluth, Richard (PI)
  • Wong-Staal, Flossie (PI)
  • Looney, David (PI)
  • Spina, Celsa (PI)
  • Bozzette, Samuel (PI)
  • Wong-Staal, Flossie (PI)
  • Torbett, Bruce Edward (PI)
  • Pond, Sergei L. Kosakovsky (PI)
  • Woelk, Christopher (PI)
  • Smith, David Mitchell (PI)
  • Schooley, Robert Turner (PI)
  • Haubrich, Richard (PI)
  • Richman, Douglas (PI)
  • Havlir, Diane (PI)
  • Mathews, W. (PI)
  • Corbeil, Jacques (PI)
  • Spector, Stephen (PI)

Project: Research project

Project Details


UCSD has made a strong commitment to AIDS research, as reflected by the
high caliber of its faculty conducting both basic and clinical research
related to HIV, and by recent plans to establish and AIDS Research
Institute as an Organized Research Unit (ORU). The goals of a CFAR at
UCSD are in accord with the goals envisioned for the AIDS Research
Institute, which are to provide mechanisms to generate improved core
research facilities, to foster interactions among researchers, to provide
support for new investigators and feasibility studies, and to provide
educational and training opportunities in the many areas related to HIV
infection. Dr. Wong-Staal will serve as P.I. and Director of the UCSD
CFAR. She will be assisted by Dr. Douglas Richman, Deputy Director, in
overseeing the performance of the CFAR. Dr. Wong-Staal and Dr. Richman
have complementary areas of expertise, and their cooperation should
strengthen he interaction of basic and clinical AIDS researcher at UCSD.
There will be three basic science cores: Molecular and two clinical
cores: Primary Virus Isolation and Specimen Banking Core Data and
Analysis Core. The thematic area of this CFAR application is "Molecular Approaches to
AIDS Therapy and Prevention". Current AIDS-related activities at UCSD
span basic studies on viral regulation, mechanisms of pathogenesis,
preclinical development of therapy and vaccine strategies and clinical
studies that impact on opportunistic infections, neurobiology and
psychiatry and clinical treatment of AIDS. In addition to R01 support
to individual investigators, there are coordinated efforts that include
the AIDS Clinical Trial Units (ACTU) for adult and pediatric patients,
a National Co-operative Vaccine Discovery Group and the NIH Postdoctoral
AIDS Research Training Grant. The multidisciplinary research goals of
the CFAR are several fold: to conduct basic research in the areas of
molecular pathogenesis and immunopathogenesis of AIDS; to utilize insight
from the basic studies to develop preclinical studies on therapy and
prevention; to design Phase I/II clinical trials based on promising
preclinical data; and to modify existing treatment regimens based on
basic research and preclinical data. Accomplishment of these goals will
be greatly facilitated from the proposed CFAR research support and
developmental cores.
Effective start/end date4/1/943/31/18


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)
  • Immunology and Microbiology(all)


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