AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS

Project: Research project

Project Details

Description

DESCRIPTION: Cardiac depression is more pronounced in the neonatal heart
than in the adult organ. The studies described in this project are
designed to achieve the overall goal of identifying the mechanism
underlying age-related (neonate versus adult) differences in the cardiac
depressant effects of volatile anesthetics. This proposal addresses two of
the three possible factors altering cardiac function: intracellular
calcium and the sensitivity of the contractile apparatus to intracellular
calcium. Using an adult versus neonatal rat model, the mechanisms
underlying the effect of volatile anesthetics on 1) intracellular calcium
regulation related specifically to influx through the L-type channel sand
calcium release from the sarcoplasmic reticulum, and 2) Ca-sensitivity of
force generation will be addressed, with the underlying hypothesis that
both factors contribute to cardiodepression secondary to volatile
anesthetics.
StatusFinished
Effective start/end date8/1/987/31/02

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)