Aerobic Exercise Intervention for Knee Osteoarthritis

Project: Research project

Project Details


DESCRIPTION (provided by applicant):
Arthritis is one of the most common causes of functional limitation and
dependency in the United States. Individuals with osteoarthritis restrict joint
motion and limit activity in order to decrease their symptoms. Traditional,
conservative medical treatment of osteoarthritis has been directed at improving
functional status through reducing joint pain and inflammation and maintaining
or restoring joint function. Exercise as an adjunct therapy in the clinical
management of patients with osteoarthritis of the knee, however, is not
uniformly accepted.
In contrast, exercise has been shown to be effective for prevention and
treatment of cardiovascular and metabolic disorders. Standard guidelines exist
for aerobic exercise prescriptions. The focus of this study is to determine if
these guidelines can also be applied to individuals with knee osteoarthritis.
Patients with knee osteoarthritis will be randomized into a control group, a
walking exercise group, and a stationary cycling exercise group. The
individuals in the exercise groups will be required to exercise three times per
week for one year using emerging public health recommendations for aerobic
exercise in the adult and aging population. Patient outcome will be assessed
using objective gait analysis measurements, knee radiographs to quantify joint
space narrowing, magnetic resonance imaging, a general health status
questionnaire (SF-36), a disease/site specific questionnaire (WOMAC), and a
visual-analog pain scale. All subjects will be studied at 0 and 52 weeks.
The central hypothesis of this work is that aerobic exercise can be
successfully implemented as an effective nonsurgical option for treatment of
patients with early stages of knee osteoarthritis. In order to evaluate this
hypothesis, the following specific aims are proposed: Specific Aim 1: Determine
the effect of aerobic exercise on patients with knee osteoarthritis. Hypothesis
A: Clinical Outcome measures will be better in patients enrolled in exercise
programs that in control patients. Hypothesis B: Quantitative measures of lower
extremity function will not decline over time in an effective aerobic exercise
program. Specific Aim 2: Determine prognostic factors that effect outcome in
patients with knee osteoarthritis. Hypothesis: A effective exercise
prescription for adults with degenerative joint disease is dependent on knee
compartment involvement, CIA stage, BMI, and type of exercise prescribed.
Effective start/end date9/1/023/31/09


  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $432,795.00
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $439,059.00
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $420,567.00
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: $451,188.00


  • Medicine(all)


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