Activation of the Secretin Receptor as a Strategy for the Treatment of Heart Failure

Project: Research project

Project Details

Description

PROJECT NARRATIVE This project is designed to utilize medicinal chemistry to optimize hits from our previous high throughput screening of small molecules with activity to mimic or enhance secretin activity at its receptor, and to demonstrate activity in a rat model of heart failure. We hope to identify drug candidates with ability to safely and effectively improve clinical outcome for patients with heart failure by targeting this receptor, with potential to enhance the ability of the heart to contract more effectively and to act on blood vessels to bring more blood to the heart and improve peripheral circulation, as well as improving appetite control and glucose metabolism.
StatusActive
Effective start/end date7/5/1711/30/22

Funding

  • National Heart, Lung, and Blood Institute: $609,636.00

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