MOLECULAR DETERMINANTS OF CRANIOFACIAL/SKELETAL DYSMORPHOGENESIS

  • Oursler, Merry Jo (PI)
  • Slavkin, Harold C. (PI)
  • Lipsky, Peter (PI)
  • Slavkin, Harold C. (PI)

Project: Research project

Project Details

Description

Congenital craniofacial malformations can be caused by a large number of
factors; genetic, environmental or the interplay of both. Recent progress
in linkage analyses and positional cloning have identified many genetic
mutations associated with human craniofacial syndromes. However, the
mechanisms of how such mutations in a gene result in an altered phenotype
require the molecular dissection of the signal transduction pathway in
tissues and cells that are elements of craniofacial development. We are
particularly interested in skeletogenesis since 25% of all congenital
malformations involve the skeleton. We have initiated 5 subtopics
focussing on the different aspects of skeletogenesis, including
transcriptional control of chondrogenesis, cell adhesion and cytoskeletal
signal transduction in chondrocyte differentiation, cranial neural crest
cell migration and differentiation, differentiative pathway of
osteo-chondro-progenitor cells under compressive force and the generation
of monoclonal antibodies against stage specific chondrocyte markers.
These subtopics are independent areas of research, yet collectively are
interrelated scientifically and technically to address some of the key
questions in the field of craniofacial development. It is our goal that
through these subtopics, we will be able to identify signal transduction
pathways elicited by intrinsic factors such as transcriptional activation,
and extrinsic factors such as cell-cell interactions and cell-substrate
interactions, leading to early events of chondrogenesis. We will also
extrapolate our knowledge of normal chondrogenesis to elucidate the
etiology of various forms of genetic diseases and disorders of the
cartilage, for the development of preventive, diagnostic and therapeutic
strategies.
StatusFinished
Effective start/end date1/1/9312/31/97

Funding

  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases

ASJC

  • Medicine(all)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.