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  Mechanisms of mechanotransduction in the enterochromaffin cells

  Beyder, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Enterochromaffin Cells 100%
  • Serotonin 39%
  • Ion Channels 32%
  • Gastrointestinal Motility 23%
  • Organoids 17%

• Quantitative Ultrasound Imaging Biomarkers of Crohn's Disease

  Chen, S. D., Chen, S. D. & Bruining, D. H.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Crohn Disease 100%
  • Ultrasonography 66%
  • Fibrosis 62%
  • Biomarkers 53%
  • Comb and Wattles 48%

• TRAINING IN TRANSLATIONAL RESEARCH--BENCH TO BEDSIDE

  Maher III, J., Maher III, J., Kinney, L., Kinney, L. & Kinney, L.

  National Institute of General Medical Sciences

  Project: Research project

  • student 100%
  • minority 92%
  • medicine 70%
  • career 64%
  • Students 64%

• Role of viral mitophagosomes in driving sex differences in myocarditis

  Fairweather, D.

  Project: Research project

  • Myocarditis 100%
  • Enterovirus 91%
  • Mitochondria 29%
  • Heart 23%
  • Heart Failure 19%

• NCI, National Clinical Trials Network Lead Academic Participating Site (LAPS) UG1

  Boughey, J. C. & Alberts, S. R.

  National Cancer Institute

  Project: Research project

  • Clinical Trials 100%
  • Research Personnel 22%
  • Organizations 20%
  • Neoplasms 10%
  • Physicians 10%

• Regulatory Action of Protease Activated Receptor 1 in Myelin Production

  Scarisbrick, I. A.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Myelin Sheath 100%
  • PAR-1 Receptor 75%
  • Oligodendrocyte Precursor Cells 44%
  • Multiple Sclerosis 37%
  • Cuprizone 26%

• Uncovering RNA signatures of C9ORF72-linked ALS and related disorders

  Van Blitterswijk, M.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Chromosomes, Human, Pair 9 100%
  • Open Reading Frames 72%
  • Amyotrophic Lateral Sclerosis 44%
  • RNA Sequence Analysis 35%
  • RNA 34%

• Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial Hypertension

  Tschumperlin, D. J. & Tschumperlin, D. J.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Pulmonary Arterial Hypertension 100%
  • Bone Morphogenetic Proteins 88%
  • Prostaglandins 58%
  • Smooth Muscle Myocytes 54%
  • Pulmonary Artery 47%

• Universal positive allosteric modulators of CCK1R without intrinsic agonist activity for the treatment of obesity

  Miller, L. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • CHO Cells 100%
  • Obesity 58%
  • cholecystokinin 58 55%
  • Cholecystokinin Receptors 39%
  • Small Molecule Libraries 39%

• Enhanced, EHR-facilitated Cancer Symptom Control (E2C2) Pragmatic Clinical Trial

  Cheville, A. L.

  National Cancer Institute

  Project: Research project

  • Pragmatic Clinical Trials 100%
  • Touch 50%
  • Patient Reported Outcome Measures 41%
  • Neoplasms 38%
  • Self-Management 26%

• Increasing Adherence to Pulmonary Rehabilitation after COPD-related Hospitalizations

  Benzo, R. P.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Chronic Obstructive Pulmonary Disease 100%
  • Rehabilitation 89%
  • Hospitalization 76%
  • Lung 65%
  • Telerehabilitation 22%

• Advances in Phase-Contrast MR Angiography

  Pipe, J. & Kinney, L.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • flow velocity 100%
  • shear stress 95%
  • method 71%
  • shear flow 61%
  • data acquisition 50%

• Step down of asthma biologics in real-world practice settings

  Rank, M. A.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Asthma 100%
  • Biological Products 99%
  • Omalizumab 48%
  • reslizumab 36%
  • mepolizumab 33%

• Cardiorenal Fibrosis: Biology and Therapeutics

  Sangaralingham, S. J.

  Project: Research project

  • C-Type Natriuretic Peptide 100%
  • Fibrosis 83%
  • Kidney 54%
  • Guanylate Cyclase 42%
  • atrial natriuretic factor receptor B 37%

• Mechanisms of Processivity in Molecular Motors

  Rosenfeld, S. & Kinney, L.

  National Institute of General Medical Sciences

  Project: Research project

  • Kinesin 100%
  • Neck 64%
  • Head 41%
  • myosin VI 24%
  • Myosin Type V 23%

• Microfabricated Biosensor Platform for Monitoring of Cell Metabolism

  Revzin, A. & Kinney, L.

  National Institute of Biomedical Imaging and Bioengineering

  Project: Research project

  • biosensors 100%
  • hepatocytes 69%
  • monitoring 52%
  • cell culture 51%
  • metabolism 46%

• Regulating pulmonary inflammation by type I IFN signaling in neutrophils during i

  Sun, J. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Eragrostis 100%
  • Interleukin-10 74%
  • Interleukin-27 72%
  • Neutrophils 60%
  • Pneumonia 57%

• Designing a Microenvironment Niche for Liver-Specific Differentiation of hESCs

  Revzin, A., Kinney, L. & Kinney, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • niches 100%
  • stem cells 98%
  • liver 77%
  • hepatocytes 72%
  • embryonic stem cells 68%

• Cell-Penetrating Aptamers Targeting Sub-Cellular Compartments

  Maher III, J.

  National Institute of General Medical Sciences

  Project: Research project

  • Nucleic Acid 100%
  • Enzyme Activity 39%
  • Toxic 17%
  • Lipid 16%
  • Cation 13%

• ADPKD: Understanding mechanisms, Discovering treatments.

  Li, X., Kinney, L. & Kinney, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Epithelial Cells 45%
  • Cysts 27%
  • TRPP Cation Channels 22%
  • Tumor Necrosis Factor-alpha 21%
  • Apoptosis 19%

• Astrocytic function in DBS for essential tremor

  Chang, S.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Essential Tremor 100%
  • Tremor 89%
  • Astrocytes 77%
  • Adenosine 41%
  • Optogenetics 36%

• Obesity-induced mesenchymal stem cell senescence

  Lerman, L. O.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Mesenchymal Stem Cells 78%
  • Obesity 59%
  • Research Subjects 20%
  • Phenotype 20%
  • Extracellular Vesicles 16%

• Precision Medicine by Targeting Cell Adhesion in Melanoma

  Meves, A.

  National Cancer Institute

  Project: Research project

  • Melanoma 100%
  • Precision Medicine 99%
  • Cell Adhesion 90%
  • Sentinel Lymph Node 25%
  • Integrins 13%

• ICAM-1 GENE EXPRESSION IN MALIGNANT GLIAL TUMORS

  Rosenfeld, S. & Rosenfeld, S.

  National Institutes of Health, National Institute of Neurological Disorders and Stroke

  Project: Research project

  • glioma 100%
  • neuroglia 83%
  • cell biology 80%
  • Glioma 79%
  • molecular biology 73%

• Phase 3 stem cell transplant for light chain amyloidosis

  Gertz, M., Gertz, M. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Amyloidosis 100%
  • Light 66%
  • Stem Cells 64%
  • Transplants 54%
  • Amyloid 41%

• The Role of Autoimmune Mechanisms in the Pathogenesis of Atrial Fibrillation

  Melduni, R.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Atrial Fibrillation 100%
  • Autoimmune Diseases 18%
  • Cytokines 9%
  • National Heart, Lung, and Blood Institute (U.S.) 7%
  • T-Lymphocytes 6%

• Targeting Dendritic Cell Subsets in Human Vagina to Elicit Local Immunity

  Oh, S. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Vagina 100%
  • Allergy and Immunology 97%
  • Sexually Transmitted Diseases 71%
  • Mucosal Immunity 67%
  • Vaccines 61%

• (PQ3) UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMAS

  Jenkins, R. B.

  National Cancer Institute

  Project: Research project

  • Glioma 100%
  • Genome-Wide Association Study 37%
  • Mutation 26%
  • Central Nervous System Neoplasms 14%
  • Preliminary Data 13%

• Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies 5/9

  Kamath, P. S., Shah, V. & Shah, V.

  National Institute on Alcohol Abuse and Alcoholism

  Project: Research project

  • Alcoholic Hepatitis 100%
  • Observational Studies 46%
  • Clinical Studies 40%
  • Clinical Trials 39%
  • Granulocyte Colony-Stimulating Factor 16%

• Phenotypes of Aging & Senescence

  LeBrasseur, N. K.

  National Institute on Aging

  Project: Research project

  • cell senescence 100%
  • senescence (aging) 94%
  • phenotype 61%
  • clinical trials 54%
  • cells 27%

• Hypertensive pregnancy disorders and future coronary artery disease

  Garovic, V. D.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Coronary Artery Disease 100%
  • Pregnancy 71%
  • Pre-Eclampsia 39%
  • Reproductive History 32%
  • Epidemiology 20%

• IMMUNOGENICITY OF A XENOGENEIC BIOARTIFICAL LIVER

  Nyberg, S. & Kinney, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Artificial Liver 100%
  • Liver 32%
  • Acute Liver Failure 21%
  • Hepatocytes 15%
  • Liver Failure 10%

• Engineering an HIV-resistant immune system for HIV cure

  Fadel, H.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • HIV-1 100%
  • Immune System 77%
  • HIV 74%
  • Hematopoietic Stem Cells 30%
  • Genetic Therapy 21%

• NATIVE NETWORK CANCER RESOURCES CENTER

  Kaur, J. S. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Alaska Natives 64%
  • American Indians 59%
  • Resources 50%
  • neoplasms 46%
  • education 20%

• Trade-offs in human observer performance, image quality metrics, and patient dose

  McCollough, C. H., Kinney, L. & Kinney, L.

  National Institute of Biomedical Imaging and Bioengineering

  Project: Research project

  • Image quality 100%
  • Imaging techniques 70%
  • Tomography 34%
  • Dosimetry 34%
  • Scanning 21%

• Genome wide association study of gene expression levels in Alzheimer's disease

  Ertekin-Taner, N. & Kinney, L.

  National Institute on Aging

  Project: Research project

  • Genome-Wide Association Study 100%
  • Alzheimer Disease 79%
  • Single Nucleotide Polymorphism 53%
  • Gene Expression 49%
  • Messenger RNA 36%

• TREM2-mediated microglial dynamic function in Alzheimer disease

  Bu, G. D.

  National Institute on Aging

  Project: Research project

  • Induced Pluripotent Stem Cells 100%
  • Pathology 93%
  • Microglia 89%
  • Alzheimer Disease 83%
  • Amyloid 55%

• Intra-Operative, Label-Free Detection of Brain Cancer Infiltration with Quantitative Optical Imaging

  Quinones-Hinojosa, A.

  National Cancer Institute

  Project: Research project

  • Optical Coherence Tomography 100%
  • Brain Neoplasms 94%
  • Optical Imaging 94%
  • Glioblastoma 35%
  • Survival 35%

• Multi-site Gastrointestinal Cancer Detection by Stool DNA Methylation

  Kisiel, J. B.

  National Cancer Institute

  Project: Research project

  • Gastrointestinal Neoplasms 100%
  • DNA Methylation 73%
  • Neoplasms 29%
  • Colorectal Neoplasms 29%
  • Adenocarcinoma 21%

• Development and Characterization of a Preclinical Swine Model of Osteogenesis Imperfecta

  Deyle, D. R.

  National Institute of Dental and Craniofacial Research

  Project: Research project

  • Osteogenesis Imperfecta 100%
  • Swine 34%
  • Bone and Bones 10%
  • Dentinogenesis Imperfecta 10%
  • Craniofacial Abnormalities 9%

• Measurements of BPDE-DNA adducts by solid state nonopore & deep sequencing (PQ3

  Kosari, F., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • trans-1,2-dihydro-1,2-naphthalenediol 100%
  • Epoxy Compounds 83%
  • Benzo(a)pyrene 78%
  • DNA Adducts 67%
  • High-Throughput Nucleotide Sequencing 43%

• CANCER AND LEUKEMIA GROUP B

  Diasio, R. B. & Diasio, R. B.

  National Institutes of Health, National Cancer Institute

  Project: Research project

  • Leukemia 100%
  • Historically Controlled Study 51%
  • Neoplasms 49%
  • Lung Neoplasms 48%
  • Population Control 36%

• Microglial apoE in neuroinflammation and Alzheimer's disease

  Fryer, J. D. & Liu, C.

  National Institute on Aging

  Project: Research project

  • Apolipoproteins E 100%
  • Microglia 83%
  • Alzheimer Disease 70%
  • Apolipoprotein E4 44%
  • Amyloid 38%

• Regional Assessment of the Lung Using Magnetic Resonance Elastography (MRE)

  McGee, K. P. & Kinney, L.

  National Institute of Biomedical Imaging and Bioengineering

  Project: Research project

  • Elasticity Imaging Techniques 100%
  • Lung 55%
  • Interstitial Lung Diseases 46%
  • Lung Diseases 38%
  • Magnetic Resonance Imaging 18%

• Harnessing Molecular Networks of Resilience for Therapeutic Discoveries in AD

  Ertekin-Taner, N.

  Project: Research project

  • Alzheimer Disease 100%
  • Pharmacogenetics 15%
  • Biomarkers 8%
  • Pathology 8%
  • Adenosine Monophosphate 7%

• HRD-IA signatures in pancreatic ductal adenocarcinoma

  Barrett, M.

  Project: Research project

  • Homologous Recombination 100%
  • Adenocarcinoma 61%
  • Neoplasms 41%
  • Genome 40%
  • Poly(ADP-ribose) Polymerase Inhibitors 26%

• 2/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center

  Parker, A.

  National Cancer Institute

  Project: Research project

  • planning 100%
  • evaluation 75%
  • neoplasms 63%
  • cancer 50%
  • mentoring 50%

• Improved Classification of Acute Kidney Injury Following Iodinated Contrast Exam

  McDonald, J. S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Acute Kidney Injury 100%
  • Contrast Media 70%
  • Nephrology 60%
  • Research Personnel 53%
  • Radiology 50%

• Admin Core

  Dasari, S.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Congenital Disorders of Glycosylation 100%
  • Glycosylation 37%
  • Research Personnel 33%
  • Communication 18%
  • Acoustic waves 16%

• Studies of translational regulatory networks in macrophage-mediated inflammatory responses

  Hu, W.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Macrophages 100%
  • Messenger RNA 88%
  • Inflammatory Bowel Diseases 55%
  • RNA-Binding Proteins 44%
  • Protein Biosynthesis 42%