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  Targeting NAD metabolism to treat systemic sclerosis

  Chini, E. N.

  Project: Research project

  • NAD 100%
  • Systemic Scleroderma 80%
  • Sirtuins 71%
  • Fibrosis 45%
  • NAD+ Nucleosidase 29%

• Multi-site Validation and Application of a Consensus DSC MRI Protocol

  Hu, L. S.

  National Cancer Institute

  Project: Research project

  • Cerebral Blood Volume 100%
  • Radiation Effects 88%
  • Recurrence 43%
  • Glioblastoma 37%
  • Brain Neoplasms 35%

• Bimodal platform for nondestructive analysis of engineered vascular biomaterials

  Griffiths, L.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Biomaterials 100%
  • Tissue 76%
  • Scaffolds 75%
  • Ultrasonics 43%
  • Tissue engineering 31%

• Smoking cessation in lung cancer screening: integrated digital/clinical approach

  Midthun, D. E.

  National Cancer Institute

  Project: Research project

  • Spiral Computed Tomography 100%
  • Smoking Cessation 63%
  • Early Detection of Cancer 62%
  • Smokers 58%
  • Lung Neoplasms 52%

• The Murine Dialysis Fistula Model Exhibits a Senescence Phenotype: Pathobiologic Mechanisms and Therapeutic Potential

  Nath, K. A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Arteriovenous Fistula 100%
  • Fistula 53%
  • Dialysis 50%
  • Phenotype 36%
  • Therapeutics 10%

• Pathogenesis of infection in pancreatitis: from sterile inflammation to sepsis

  Singh, V. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Pancreatitis 100%
  • Sepsis 78%
  • Inflammation 46%
  • Infections 39%
  • Unsaturated Fatty Acids 17%

• Girk2/3 channels in cartilage biology and disease

  Westendorf, J. J.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Project: Research project

  • osteoblasts 100%
  • chondrocytes 97%
  • cartilage 70%
  • bones 57%
  • Biological Sciences 44%

• Congenital Myasthenic Syndromes

  Engel, A. G. & Selcen, D.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Congenital Myasthenic Syndromes 100%
  • Genes 24%
  • Phenotype 21%
  • Whole Exome Sequencing 14%
  • Safety 13%

• Therapeutic modulation of zinc for lung injury and mechanobiology

  Tschumperlin, D. J.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Biophysics 100%
  • Zinc 92%
  • Lung Injury 77%
  • Adult Respiratory Distress Syndrome 19%
  • Therapeutics 12%

• Assessment of Alcoholic Hepatitis with Multiparametric Magnetic Resonance Elastography

  Yin, M. & Shah, V.

  National Institute on Alcohol Abuse and Alcoholism

  Project: Research project

  • Alcoholic Hepatitis 100%
  • Elasticity Imaging Techniques 83%
  • Multiparametric Magnetic Resonance Imaging 25%
  • interleukin-22 22%
  • AA005 19%

• Bridging the gap: Angiogenesis and stem cell seeding of processed nerve allograft

  Shin, A. Y.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Allografts 100%
  • Mesenchymal Stem Cells 98%
  • Stem Cells 68%
  • Schwann Cells 41%
  • Gene Expression 32%

• Molecular imaging and system dynamics of tumor virotherapy

  Dingli, D. M., Kinney, L. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Molecular Imaging 100%
  • Viruses 40%
  • Neoplasms 32%
  • Measles virus 21%
  • Vesicular Stomatitis 14%

• ST8Sia6 protects against the immune response

  Shapiro, V. M.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Type 1 Diabetes Mellitus 28%
  • Islets of Langerhans Transplantation 26%
  • N-Acetylneuraminic Acid 24%
  • Streptozocin 21%

• A research opportunity index to measure biomedical research disparities across the disease landscape.

  Yao, L.

  Project: Research project

  • biomedical research 100%
  • resource allocation 73%
  • funding 70%
  • burden of disease 61%
  • public health 59%

• Translational Geroscience Network

  Kirkland, J. L. & Tchkonia, T.

  National Institute on Aging

  Project: Research project

  • Data Management 100%
  • Proteostasis 97%
  • Clinical Trials 97%
  • Idiopathic Pulmonary Fibrosis 90%
  • Organized Financing 88%

• Development of a novel Balloon Occlusion Sheath for Stroke (BOSS)

  Kallmes, D. F. & Kallmes, D. F.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Balloon Occlusion 100%
  • Stroke 48%
  • Equipment and Supplies 36%
  • Embolectomy 28%
  • Embolism 10%

• Novel Therapeutics Targeting INPP5A Pathway in Squamous Cell Carcinoma

  Sekulic, A. D. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Squamous Cell Carcinoma 100%
  • Basal Cell Carcinoma 22%
  • Therapeutics 18%
  • Neoplasms 15%
  • Phytic Acid 14%

• Autoimmune Mechanisms in Human Myocarditis

  Cooper, L. T. J.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Myocarditis 100%
  • Cardiac Myosins 52%
  • Dilated Cardiomyopathy 22%
  • Monocytes 21%
  • Heart Failure 18%

• Novel entropy based identification of rotors in human atrial fibrillation

  Mulpuru, S.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Entropy 100%
  • Atrial Fibrillation 94%
  • Pulmonary Veins 23%
  • Preliminary Data 22%
  • Cardiac Arrhythmias 17%

• Eosinophil Regulation of Pulmonary IL-13 Levels

  Jacobsen, E. & Kinney, L.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Eosinophils 100%
  • Interleukin-13 73%
  • Asthma 53%
  • Lung 51%
  • Pulmonary Eosinophilia 40%

• Administrative Core

  Kantarci, K. M., Boeve, B. F., Dickson, D. W. & Knopman, D. S.

  National Institute on Aging

  Project: Research project

  • Frontotemporal Lobar Degeneration 100%
  • Alzheimer Disease 96%
  • dementia 96%
  • Organized Financing 83%
  • Biomarkers 73%

• The role of nuclear PD-L1 in breast tumor cell division, progression and therapy response

  Lou, Z. & Wang, L. M.

  National Cancer Institute

  Project: Research project

  • Ligands 100%
  • Cell Division 91%
  • Cell- and Tissue-Based Therapy 91%
  • Triple Negative Breast Neoplasms 83%
  • Breast Neoplasms 66%

• High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

  Rossoll, W.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Ciliary Neurotrophic Factor Receptor 100%
  • Amyotrophic Lateral Sclerosis 58%
  • Ciliary Neurotrophic Factor 44%
  • Motor Neurons 30%
  • Nerve Growth Factors 26%

• Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma

  Guerrero Cazares, H.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Lateral Ventricles 100%
  • Osteopontin 91%
  • Glioblastoma 84%
  • Cerebrospinal Fluid 74%
  • Neoplasms 26%

• Non-Invasive Localization of Vulnerable Plaques

  McCollough, C. H., Kinney, L. & Kinney, L.

  National Institute of Biomedical Imaging and Bioengineering

  Project: Research project

  • Iron 100%
  • Tomography 50%
  • Calcium 44%
  • Rupture 31%
  • Erythrocytes 14%

• VACCINE FOR PATIENTS WITH NON HODGKINS LYMPHOMA

  Chanan Khan, A. A.

  National Cancer Institute

  Project: Research project

  • Non-Hodgkin's Lymphoma 100%
  • Peptides 84%
  • Lymphoma 83%
  • Vaccines 79%
  • Immunoglobulins 58%

• Novel genetic modifiers of C9orf72 and Tau toxicity

  Fryer, J. D. & Petrucelli, L.

  National Institute on Aging

  Project: Research project

  • Collaborative Cross Mice 100%
  • Dependovirus 65%
  • Frontotemporal Dementia With Motor Neuron Disease 49%
  • Frontotemporal Lobar Degeneration 14%
  • Validation Studies 11%

• Enhancing Treatment Response by Leveraging STAT5-OLIG2 signaling in GBM

  Tran, N.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Glioblastoma 100%
  • Glioma 57%
  • epidermal growth factor receptor VIII 56%
  • Temozolomide 32%
  • Stem Cells 32%

• International Conference on Advances in Quantitative Laryngology, Voice and Speech Research (AQL)

  Lott, D. G.

  National Institute on Deafness and Other Communication Disorders

  Project: Research project

  • continuity 100%
  • website 96%
  • student 73%
  • planning 71%
  • pathology 57%

• Genetic Biomarkers for Risk of CLL Progression among high-count MBLs

  Slager, S. L.

  National Cancer Institute

  Project: Research project

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Lymphocytosis 98%
  • B-Lymphocytes 86%
  • Biomarkers 48%
  • Asymptomatic Diseases 48%

• Neuronal antigen surveillance and autoimmunity in CNS demyelinating disease

  Howe, C. L.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Demyelinating Diseases 100%
  • T-Lymphocytes 88%
  • Central Nervous System Diseases 83%
  • Axons 83%
  • Multiple Sclerosis 75%

• Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial

  Khosla, S.

  National Institute on Aging

  Project: Research project

  • Atenolol 100%
  • Postmenopausal Osteoporosis 84%
  • Osteoporosis 80%
  • Bone and Bones 61%
  • Randomized Controlled Trials 38%

• SURGICAL PLANNING WITH REAL TIME MOTION CORRECTED FMRI

  Jack, C. R. J.

  National Cancer Institute

  Project: Research project

  • Magnetic Resonance Imaging 100%
  • Head 73%
  • Brain Mapping 68%
  • Brain Neoplasms 46%
  • Neurosurgical Procedures 33%

• Airway Structural Cells and Corticosteroid Resistance in Asthma

  Britt, R. J.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Adrenal Cortex Hormones 100%
  • Smooth Muscle 85%
  • Asthma 72%
  • Airway Remodeling 28%
  • Inflammation 25%

• Role of Spp1 on microglia and Alzheimer's disease

  Kang, S.

  National Institute on Aging

  Project: Research project

  • Tauopathies 100%
  • Amyloidosis 98%
  • Osteopontin 87%
  • Microglia 82%
  • Gliosis 52%

• Artificial Intelligence-Based Approaches for Renal Structure Characterization in Computed Tomography Images

  Kline, T.

  Project: Research project

  • Imaging techniques 100%
  • Biomarkers 40%
  • Biopsy 21%
  • Image acquisition 18%
  • Pathology 18%

• Non-invasive imaging of progenitor cell fate in the ischemic myocardium

  Rodriguez-Porcel, M. G. & Kinney, L.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Oxidants 100%
  • Myocardium 71%
  • Reporter Genes 57%
  • Stem Cells 49%
  • Antioxidants 28%

• Role of NOX4 and redox environment in Autosomal Dominant Polycystic Kidney Disease

  Irazabal Mira, M.

  Project: Research project

  • NADPH Oxidase 4 100%
  • Cyclic AMP-Dependent Protein Kinases 46%
  • Up-Regulation 32%
  • Oxidation-Reduction 30%
  • Disease Progression 30%

• Effects of senescence to Alzheimer's disease pathology

  Baker, D. J.

  National Institute on Aging

  Project: Research project

  • Neurodegenerative Diseases 100%
  • Pathology 68%
  • Alzheimer Disease 66%
  • Preliminary Data 31%
  • Drive 29%

• Accelerating Dissemination of Implantable Neurotechnology for Clinical Research

  Worrell, G. A.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Equipment and Supplies 100%
  • Research Personnel 83%
  • Movement Disorders 53%
  • Software Validation 42%
  • Adaptive Clinical Trials 42%

• Optimization of antigen preparations from Coccidioides for diagnostic testing

  Grys, T.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Coccidioides 100%
  • Mycelium 94%
  • Antigens 70%
  • Coccidioidomycosis 67%
  • Chitinases 50%

• IMPLEMENTATION OF DMOL &COSMO PROGRAM ON CRAY T3D: MOLEC STRUCT

  Sine, S. M.

  National Center for Research Resources

  Project: Research project

  • Molecular Dynamics Simulation 100%
  • Nicotinic Receptors 99%
  • Drug Discovery 92%
  • Organized Financing 53%
  • Workflow 49%

• CORE--STAINING AND RECONSTRUCTION OF NEURONS AND THEIR PROCESSES IN 3-DIMENSIONS

  Salisbury, J. L.

  National Center for Research Resources

  Project: Research project

  • Protein 100%
  • Organism 93%
  • breast 87%
  • tumors 79%
  • Cells 58%

• COBRE Molecular Basis of Human Disease

  Liu, J. D.

  National Center for Research Resources

  Project: Research project

  • human disease 100%
  • grant 20%
  • research project 20%
  • funding 17%
  • program 16%

• T CELL DIVERSITY &TURNOVER IN HUMAN AUTOIMMUNE DISEASE

  Goronzy, J.

  National Institute of General Medical Sciences

  Project: Research project

  • Autoimmune Diseases 100%
  • T-Lymphocytes 92%
  • Research Personnel 27%
  • Clone Cells 15%
  • To autoantigen 14%

• Adipose-derived biogenic nanoparticles for treatment of myocarditis/DCM(MPDPI)

  Wolfram, J. & Fairweather, D.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Myocarditis 100%
  • Dilated Cardiomyopathy 84%
  • Nanoparticles 70%
  • Toll-Like Receptor 4 41%
  • Anti-Inflammatory Agents 21%

• Turning K-12 Environmental STEM Education InSciEd Out

  Pierret, C. K.

  National Institute of General Medical Sciences

  Project: Research project

  • mathematics 100%
  • engineering 88%
  • education 49%
  • medication 38%
  • Environmental toxicology 26%

• Multi-energy CT with Energy-integrating Detector

  Yu, L.

  National Institute of Biomedical Imaging and Bioengineering

  Project: Research project

  • Photons 100%
  • Detectors 68%
  • Imaging techniques 38%
  • X rays 23%
  • Phantoms 18%

• The role of microglia in neuromyelitis optica

  Lennon, V. A. & Wu, L.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Neuromyelitis Optica 100%
  • Microglia 60%
  • Astrocytes 32%
  • Immunoglobulin G 22%
  • Central Nervous System 17%

• Hypoxic preconditioning for the improvement of the regenerative capacity of adipose-derived mesenchymal stem cells and its application in chronic kidney disease due to hypertensive nephropathy

  Herrmann, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Hypertensive Nephropathy 100%
  • Chronic Renal Insufficiency 45%
  • Mesenchymal Stem Cells 44%
  • Swine 14%
  • Regenerative Medicine 13%