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• Role of Integrins in Cardiac Myocyte Function

  Loftus, J. C. & Kinney, L.

  National Heart, Lung, and Blood Institute

  9/30/01 → 7/31/06

  Project: Research project

  • Integrins 100%
  • Cardiac Myocytes 91%
  • Muscle Cells 47%
  • Extracellular Matrix 35%
  • G-Protein-Coupled Receptors 31%

• Role of Immunity in Efficacy of Chemotherapy Plus Trastuzumab

  Clynes, R., Knutson, K. L., Knutson, K. L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  1/1/11 → 12/31/16

  Project: Research project

  • Trastuzumab 100%
  • Immunity 58%
  • Drug Therapy 44%
  • Breast Neoplasms 23%
  • Antibody Formation 13%

• Role of IL-9 in Treg Biology and Tumor Immunity

  Gendler, S. J., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  5/1/11 → 2/29/16

  Project: Research project

  • Regulatory T-Lymphocytes 65%
  • Immunity 46%
  • Neoplasms 21%
  • Vaccination 12%
  • Transgenic Mice 12%

• Role of ICAM1 in development and progression of pancreatic cancer

  Storz, P.

  National Cancer Institute

  Project: Research project

  • Pancreatic Neoplasms 100%
  • Macrophages 84%
  • Adenocarcinoma 35%
  • Interleukin-13 17%
  • Chemotactic Factors 17%

• Role of Human Cerebrospinal Fluid Chemokines in the Invasiveness of Human Glioblastoma

  Guerrero Cazares, H.

  National Cancer Institute

  Project: Research project

  • Glioblastoma 100%
  • Cerebrospinal Fluid 90%
  • Brain Neoplasms 80%
  • Chemokines 80%
  • Neoplastic Stem Cells 76%

• Role of HSulf-1 Loss in Apoptosis and Drug Resistance

  Shridhar, V. & Kinney, L.

  National Cancer Institute

  3/1/04 → 2/28/09

  Project: Research project

  • Ovarian Neoplasms 100%
  • Drug Resistance 84%
  • Down-Regulation 59%
  • Apoptosis 59%
  • heparin proteoglycan 40%

• Role of HLA-DR3 in pathogenesis of Systemic lupus erythematosus(SLE)

  Chowdhary, V. R.

  National Institutes of Health

  9/1/10 → 5/31/15

  Project: Research project

  • HLA-DR3 Antigen 100%
  • Systemic Lupus Erythematosus 64%
  • T-Lymphocytes 41%
  • Peptides 28%
  • Antigens 28%

• Role of HLA class II genes in demyelination

  David, C. S.

  National Institutes of Health

  4/1/06 → 7/31/15

  Project: Research project

  • MHC Class II Genes 100%
  • Demyelinating Diseases 79%
  • sclerosis 72%
  • Multiple Sclerosis 68%
  • Transgenic Mice 46%

• Role of Fumarate and Nrf2 response in the pathogenesis of Autosomal Dominant Polycystic Kidney Disease

  Irazabal Mira, M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Fumarates 100%
  • Kidney 18%
  • Masoprocol 17%
  • Metabolomics 12%
  • Ubiquitination 12%

• Role of force regulated nuclear structure in expression of osteogenesis

  van Wijnen, A. J.

  Project: Research project

  • Actins 100%
  • Catenins 49%
  • Osteogenesis 43%
  • Polymerization 40%
  • Gene Expression 35%

• Role of FOG2/GATA3 complex in lung cancer metastasis

  Yang, Y. D.

  Project: Research project

• Role of Endothelial Progenitor Cells in vascular Aging and Calcification

  Khosla, S., Lerman, A., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Institute on Aging

  4/15/10 → 3/31/15

  Project: Research project

  • Vascular Calcification 100%
  • Endothelial Progenitor Cells 94%
  • Vascular Diseases 32%
  • Osteoporosis 26%
  • Bone and Bones 23%

• Role of CPT1A as a lysine succinyltransferase in tumorigenesis

  Hitosugi, T. D.

  National Cancer Institute

  Project: Research project

  • Lysine 100%
  • Carnitine O-Palmitoyltransferase 66%
  • Carcinogenesis 65%
  • Breast Neoplasms 47%
  • Phosphorylation 23%

• Role of Circadian Misalignment in Beta-cell Failure in Type 2 Diabetes

  Matveyenko, A. V. & Kinney, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  7/1/13 → 6/30/18

  Project: Research project

  • Type 2 Diabetes Mellitus 100%
  • Circadian Clocks 92%
  • Circadian Rhythm 48%
  • Oxidative Stress 42%
  • Insulin-Secreting Cells 41%

• Role of CD38 in NAD metabolism: from the basic biology of aging to translation

  Chini, E. N.

  National Institute on Aging

  Project: Research project

  • NAD 100%
  • NAD+ Nucleosidase 26%
  • Longevity 14%
  • nicotinamide-beta-riboside 14%
  • Formoterol Fumarate 11%

• Role of CC chemokine signaling in hyperglycemic renal artery stenosis

  Grande, J. P., Kinney, L. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  3/15/13 → 2/28/18

  Project: Research project

  • CC Chemokines 100%
  • Renal Artery Obstruction 88%
  • Renovascular Hypertension 67%
  • Kidney 43%
  • Metabolic Syndrome 33%

• Role of Carotid Bodies in Glucose Regulation and Counter Regulation in Humans

  Basu, R., Joyner, M. J., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  2/1/11 → 1/31/16

  Project: Research project

  • Carotid Body 100%
  • Hypoglycemia 62%
  • Glucose 40%
  • Blood Glucose 23%
  • Type 1 Diabetes Mellitus 22%

• ROLE OF CADML IN EMBRYONIC AND LYMPHOCYTE DEVELOPMENT

  Bram, R. J.

  National Cancer Institute

  12/16/99 → 11/30/05

  Project: Research project

  • Cyclophilins 100%
  • Embryonic Development 56%
  • Ligands 48%
  • Calcium 46%
  • Lymphocytes 40%

• Role of BubR1 as a juvenile protective factor in hippocampal aging

  Jang, M. D.

  Project: Research project

• role of BLyS/April in Normal and Malignant Plasma Cells

  Jelinek, D. F. & Kinney, L.

  National Cancer Institute

  2/7/04 → 7/31/09

  Project: Research project

  • B-Cell Activating Factor 100%
  • Plasma Cells 62%
  • B-Cell Maturation Antigen 36%
  • Ligands 33%
  • B-Lymphocytes 24%

• Role of Bim and soluble B7-H1 in monitoring T cell responses to anti-PD-1 therapy in melanoma

  Dong, H. M., Dronca, R., Dronca, R. S. & Dronca, R. S.

  National Cancer Institute

  8/17/15 → 7/31/17

  Project: Research project

  • Melanoma 100%
  • T-Lymphocytes 74%
  • Therapeutics 25%
  • pembrolizumab 25%
  • Neoplasms 20%

• Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice

  Taneja, V. D. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  7/15/09 → 6/30/14

  Project: Research project

  • arthritis 100%
  • B-lymphocytes 87%
  • pathogenesis 69%
  • collagen 67%
  • mice 47%

• Role of atypical PKCs in Pancreatic Tumor Growth and Metastasis

  Murray, N. R. & Kinney, L.

  National Cancer Institute

  9/28/09 → 8/31/13

  Project: Research project

  • Protein Kinases 100%
  • Pancreatic Neoplasms 93%
  • Neoplasm Metastasis 60%
  • Growth 49%
  • Adenocarcinoma 46%

• ROLE OF A TGF-BETA REGULATED GENE IN HUMAN OSTEOBLASTS

  Hawse, J. R., Subramaniam, M., Spelsberg, T. C., Spelsberg, T. C., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Institute of Dental and Craniofacial Research

  9/1/01 → 6/30/17

  Project: Research project

  • Skeleton 100%
  • Osteoblasts 98%
  • Wnt Signaling Pathway 76%
  • Estrogens 64%
  • Transforming Growth Factor beta 52%

• Role of a Novel TROY-EGFR Complex in Gliobastoma Invasion and Resistance

  Loftus, J. C.

  National Institute of Neurological Disorders and Stroke

  3/1/15 → 2/29/20

  Project: Research project

  • Glioblastoma 100%
  • Rho Guanine Nucleotide Exchange Factors 52%
  • Epidermal Growth Factor 24%
  • Temozolomide 20%
  • Cell Movement 20%

• Role of ALX in CD28 signaling

  Shapiro, V. M. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  7/1/04 → 6/30/10

  Project: Research project

  • T-Cell Antigen Receptor 100%
  • T-Lymphocytes 98%
  • Interleukin-2 54%
  • MAP Kinase Kinase Kinases 50%
  • Jurkat Cells 29%

• Role of Alcohol and Circadian Disruption in Inflammation and Colon Cancer

  Khazaie, K., Kinney, L., Kinney, L. & Khazaie, K.

  National Institute on Alcohol Abuse and Alcoholism

  2/5/14 → 1/31/19

  Project: Research project

  • Colonic Neoplasms 100%
  • Alcohols 88%
  • Circadian Rhythm 86%
  • Inflammation 68%
  • Shift Work Schedule 52%

• Role of Adenosine in Compensatory Dilation During Hypoxic Exercise

  Casey, D. P.

  National Institutes of Health

  7/23/08 → 7/22/11

  Project: Research project

  • Adenosine 100%
  • Vasodilation 98%
  • Dilatation 67%
  • Hypoxia 64%
  • Vasodilator Agents 61%

• Rochester Epidemiology Project

  Rocca, W. A., Kurland, L. & Jacobsen, S.

  9/1/81 → 6/30/10

  Project: Research project

  • epidemiology 100%
  • grant 64%
  • data security 51%
  • renewal application 35%
  • resident 26%

• Rochester Epidemiology Project

  Yawn, B. P., Yawn, B. P., St. Sauver, J., St. Sauver, J., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Institute on Aging

  7/1/10 → 5/31/20

  Project: Research project

  • Multiple Chronic Conditions 100%
  • Multimorbidity 90%
  • Epidemiology 52%
  • United States Dept. of Health and Human Services 19%
  • epidemiology 12%

• RNA Processing Defects in SMA and Their Contribution to the Disease Phenotype

  Rossoll, W.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Spinal Muscular Atrophy 100%
  • Motor Neurons 76%
  • RNA 48%
  • Phenotype 42%
  • Axons 26%

• RNA foci in C9FTD/ALS

  Petrucelli, L. & Kinney, L.

  National Institute of Neurological Disorders and Stroke

  7/1/13 → 6/30/16

  Project: Research project

  • Amyotrophic Lateral Sclerosis 100%
  • RNA 69%
  • RNA-Binding Proteins 37%
  • Frontotemporal Lobar Degeneration 30%
  • Neurodegenerative Diseases 18%

• RNA Decoys for DNA Binding Proteins

  Maher III, J. & Kinney, L.

  National Institute of General Medical Sciences

  2/1/04 → 1/31/09

  Project: Research project

  • DNA-Binding Proteins 100%
  • Genetic Selection 81%
  • RNA 68%
  • NF-kappa B 66%
  • Yeasts 50%

• RLMP SOFTWARE SUPPORT

  Barry, M. A., Michels, C. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  5/31/96 → 5/30/12

  Project: Research project

  • Adenovirus Vaccines 100%
  • HIV-1 53%
  • Vaccines 46%
  • Mucosal Immunity 32%
  • Immunization 22%

• Risk Prediction for Breast Cancer: A Tissue-Based Strategy

  Hartmann, L. C. & Pankratz, V. S.

  National Institutes of Health

  9/15/08 → 7/31/13

  Project: Research project

  • Breast Neoplasms 100%
  • Breast Diseases 98%
  • Breast 34%
  • Epidemiologic Factors 34%
  • Risk Assessment 28%

• Risk Prediction and Mechanistic Evaluation of Postoperative Acute Lung Injury

  Kor, D. J.

  National Heart, Lung, and Blood Institute

  7/16/12 → 6/30/15

  Project: Research project

  • Acute Lung Injury 100%
  • Mentoring 16%
  • Allergy and Immunology 16%
  • Medical Informatics 12%
  • Lung 8%

• Risk of Herpes Zoster Among Adults with Asthma

  Juhn, Y. J.

  National Institutes of Health

  7/1/12 → 12/31/14

  Project: Research project

  • Herpes Zoster 100%
  • Asthma 67%
  • Herpes Zoster Vaccine 41%
  • Cellular Immunity 8%
  • Child 6%

• RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN THE COMMUNITY

  Ashrani, A. A., Bailey, K. R., Heit, J. A., Kinney, L., Kinney, L. & Bailey, K. R.

  National Heart, Lung, and Blood Institute

  4/1/01 → 5/31/20

  Project: Research project

  • Venous Thromboembolism 100%
  • Genetic Variation 10%
  • Population 9%
  • cancer procoagulant 8%
  • Cohort Studies 7%

• Risk factors for breast cancer molecular subtypes

  Kerlikowske, K., Vachon, C. M., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  4/1/10 → 1/31/16

  Project: Research project

  • Breast Neoplasms 100%
  • Breast Density 89%
  • Mammography 12%
  • Case-Control Studies 11%
  • Epidermal Growth Factor 11%

• Risk and penetrance of mutations from breast cancer testing panels.

  Couch, F. J., Goldgar, D. E., Nathanson, K. L., Nathanson, K. L., Goldgar, D. E., Goldgar, D. E. & Nathanson, K. L.

  National Cancer Institute

  9/25/14 → 8/31/19

  Project: Research project

  • Penetrance 100%
  • Breast Neoplasms 62%
  • Mutation 55%
  • Genes 33%
  • Neoplasms 13%

• RhoB in cancer pathogenesis and as a target in combinatorial therapy

  Copland, J. A. I., Smallridge, R., Smallridge, R. C., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  7/1/10 → 4/30/16

  Project: Research project

  • efatutazone 100%
  • Anaplastic Thyroid Carcinoma 79%
  • rhoB GTP-Binding Protein 22%
  • Paclitaxel 21%
  • Neoplasms 17%

• Reverse apoE4 effects by apoE2 expression in Alzheimer's disease

  Kanekiyo, T.

  National Institute on Aging

  Project: Research project

  • Apolipoprotein E2 100%
  • Apolipoprotein E4 89%
  • Alzheimer Disease 53%
  • Amyloid 46%
  • Apolipoproteins E 26%

• Retrovirus Entry and Virus Evolution

  Federspiel, M. J. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  9/30/03 → 12/31/08

  Project: Research project

  • Avian Leukosis Virus 100%
  • Retroviridae 88%
  • Virus Internalization 81%
  • Glycoproteins 72%
  • Virus Receptors 20%

• RETINAL GANGLION CELL PROCESSING OF SPATIAL INFORMATION

  Marmorstein, A. D. & Troy, J.

  National Eye Institute

  8/1/86 → …

  Project: Research project

  • Retinal Pigment Epithelium 100%
  • Proteins 31%
  • Neural Cell Adhesion Molecules 19%
  • Retina 17%
  • sodium-translocating ATPase 15%

• Retargeted Oncolytic Measles Viruses Displaying Single-Chain Antibodies

  Peng, K. & Kinney, L.

  National Cancer Institute

  6/1/06 → 4/30/12

  Project: Research project

  • Measles virus 100%
  • Oncolytic Viruses 96%
  • Single-Chain Antibodies 87%
  • Neoplasms 25%
  • Ligands 24%

• RESPONSE OF GH-DEFICIENT CHILDREN TO TREATMENT WITH HUMAN GH

  Goronzy, J.

  Project: Research project

• RESPIRATORY PUMP FAILURE--APPLIED PHYSIOLOGY

  Hubmayr, R. D.

  National Institutes of Health

  9/1/88 → 11/30/92

  Project: Research project

  • Diaphragm 100%
  • Respiratory Insufficiency 78%
  • Fatigue 49%
  • Dogs 16%
  • Pressure 15%

• RESPIRATORY MUSCLES DURING DEVELOPMENT

  Sieck, G. C. & Sieck, G. C.

  National Heart, Lung, and Blood Institute, National Institutes of Health

  7/1/86 → 3/31/03

  Project: Research project

  • Respiratory Muscles 100%
  • Muscle Development 95%
  • Diaphragm 82%
  • Fatigue 47%
  • muscle development 38%

• RESPIRATORY MECHANICS IN NORMAL AND ABNORMAL STATES

  Hubmayr, R. D., Rehder, K. A. I., vanhoutte, P., Wilson, T., Gillespie, D., De Troyer, A., Hyatt, R., Rehder, K. A. I. & Rodarte, J.

  National Institutes of Health

  9/30/77 → 11/30/92

  Project: Research project

  • Mechanics 100%
  • Respiratory Muscles 78%
  • Anesthetics 56%
  • Respiratory Mechanics 43%
  • Airway Resistance 39%

• Respiratory Control in Old Age

  Mantilla, C. B., Sieck, G. C., Kinney, L., Kinney, L. & Sieck, G. C.

  National Institute on Aging

  6/1/13 → 5/31/18

  Project: Research project

  • Diaphragm 100%
  • Sarcopenia 53%
  • Muscles 39%
  • Motor Neurons 35%
  • Neuregulin-1 27%