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  Apoptotic neuronal cells serve as sources for spreading of human a-synuclein pathology in the brain

  Jiang, P.

  National Institute of Neurological Disorders and Stroke

  9/30/16 → 8/31/18

  Project: Research project

  • Synucleins
  • Parkinson Disease
  • Pathology
  • Nuclear Envelope
  • Brain

• The Mayo GBM Xenograft National Resource

  Sarkaria, J. N.

  National Institute of Neurological Disorders and Stroke

  9/30/16 → 5/31/20

  Project: Research project

  • glioblastoma
  • neoplasms
  • translational medical research
  • peers
  • chemical species

• Senescence-related Proteins and Growth and Differentiation Factors as Modifiers of Aging

  LeBrasseur, N. K.

  National Institute on Aging

  9/30/16 → 5/31/18

  Project: Research project

  • Growth Differentiation Factors
  • Plasminogen Activator Inhibitor 2
  • Proteins
  • Walking Speed
  • Physical Functional Performance

• Attenuation Measuring Ultrasound Shearwave Elastography (AMUSE) for Noninvasive Assessment of Acute Cellular Rejection in Post-transplant Liver Patients

  Chen, S. D.

  National Institute of Biomedical Imaging and Bioengineering

  9/30/16 → 7/31/18

  Project: Research project

  • Elasticity Imaging Techniques
  • Transplants
  • Liver
  • Viscosity
  • Elasticity

• Metadata applications on informed content to facilitate biorepository data regulation and sharing

  Tao, C. D.

  National Institutes of Health

  9/28/16 → 7/31/19

  Project: Research project

  • Metadata
  • Ontology
  • Medicine
  • Information systems
  • Semantics

• Understanding Caregiving in Heart Failure and Impact on Outcomes

  Dunlay, S. M.

  National Heart, Lung, and Blood Institute

  9/20/16 → 8/31/18

  Project: Research project

  • Heart Failure
  • Caregivers
  • Social Support
  • Social Networking
  • Spouses

• Tools for standardizing clinical research metadata using HL7 FHIR

  Jiang, G. D.

  National Human Genome Research Institute

  9/15/16 → 8/31/19

  Project: Research project

  • Clinical research
  • Metadata
  • Interoperability
  • Standardization
  • Big data

• AAOS/ORS Translating Orthopaedic Technologies into Clinical Practice: Pathways from Novel Idea to Improvements in Standard of Care Research Symposium

  Yaszemski, M. J.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  9/1/16 → 8/31/17

  Project: Research project

  • ORALIT
  • Critical Pathways
  • Standard of Care
  • Orthopedics
  • Technology

• Development, Validation, and Application of an Imaging based CVD Scale

  Vemuri, P. D.

  National Institute of Neurological Disorders and Stroke

  9/1/16 → 5/31/21

  Project: Research project

  • Pathology
  • White Matter
  • Organized Financing
  • Cerebrovascular Disorders
  • Cognition

• Targeting matrix stiffness in lung and liver fibrosis

  Shah, V. & Tschumperlin, D. J.

  National Heart, Lung, and Blood Institute

  8/15/16 → 4/30/20

  Project: Research project

  • Liver Cirrhosis
  • Hepatic Stellate Cells
  • Lung
  • Fibroblasts
  • Elasticity Imaging Techniques

• Aging and Resiliency in Mice: Optimizing Assessment Protocols and Testing Interventions

  LeBrasseur, N. K. & Miller, J. D.

  National Institute on Aging

  8/15/16 → 4/30/21

  Project: Research project

  • Longevity
  • Healthy Aging
  • Frailty
  • Dehydration
  • Sirolimus

• Translational Molecular and Cellular Imaging Technologies for Prostate Tumor Pathology

  Cheville, J.

  National Institutes of Health

  8/4/16 → 7/31/19

  Project: Research project

  • Molecular Imaging
  • Prostate
  • Technology
  • Pathology
  • Prostatic Neoplasms

• REAL-TIME FEEDBACK TO IMPROVE COLONOSCOPY

  De Groen, P. C.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/1/16 → 5/31/20

  Project: Research project

  • Colonoscopy
  • Colorectal Neoplasms
  • Gastroenterology
  • Polyps
  • Colon

• Definitive Preclinical Studies of Hydrolase Gene Transfer to Treat Cocaine Abuse

  Brimijoin, W. S. & Peng, K.

  National Institute on Drug Abuse

  8/1/16 → 7/31/18

  Project: Research project

  • Cocaine-Related Disorders
  • Hydrolases
  • Transfer (Psychology)
  • Cocaine
  • Genes

• Toward new classification criteria for mild and moderate TBI by a data-inclusive cross-study analysis using FITBIR

  Jing, L. & Schwedt, T. J.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  7/22/16 → 6/30/18

  Project: Research project

  • Brain Concussion
  • Traumatic Brain Injury
  • Wounds and Injuries
  • Neurologic Manifestations
  • Nervous System Diseases

• Pharmacogenomics of Treatment Outcomes in Alcohol Use Disorders

  Biernacka, J. M., Karpyak, V. & Karpyak, V. M.

  National Institute on Alcohol Abuse and Alcoholism

  7/15/16 → 6/30/18

  Project: Research project

  • Acamprosate
  • Naltrexone
  • Pharmacogenetics
  • Alcoholism
  • Genome-Wide Association Study

• Maintenance and targeting of bone marrow derived allo-reactive human plasma cells

  Medina, K. L., Stegall, M. D. & Stegall, M. D.

  National Institute of Allergy and Infectious Diseases

  7/1/16 → 6/30/18

  Project: Research project

  • Plasma Cells
  • Isoantibodies
  • Bone Marrow
  • Maintenance
  • Tissue Donors

• Targeting MMP-9 for breast cancer therapy (R21 CA205471 Resubmission)

  Radisky, E. S.

  National Cancer Institute

  7/1/16 → 6/30/18

  Project: Research project

  • Tissue Inhibitor of Metalloproteinase-1
  • Matrix Metalloproteinase 9
  • Breast Neoplasms
  • Matrix Metalloproteinase Inhibitors
  • Matrix Metalloproteinases

• CD8 T cell mediated disruption of Blood Brain Barrier Tight Junctions

  Johnson, A. J.

  National Institutes of Health

  7/1/16 → 6/30/17

  Project: Research project

  • Tight Junctions
  • Blood-Brain Barrier
  • Capillary Permeability
  • Intercellular Signaling Peptides and Proteins
  • T-Lymphocytes

• Mechanism of calcium potentiation of alpha7 nicotinic receptors

  Sine, S. M.

  National Institute of Neurological Disorders and Stroke

  7/1/16 → 6/30/20

  Project: Research project

  • Nicotinic Receptors
  • Calcium
  • Divalent Cations
  • Drug Design
  • Ions

• Localized measurement and mapping of tissue nonlinear elasticity

  Alizad, A. & Fatemi, M.

  National Institute of Biomedical Imaging and Bioengineering

  7/1/16 → 6/30/18

  Project: Research project

  • elastic properties
  • sound waves
  • breast
  • S waves
  • pathology

• Comparative Effectiveness of Biofeedback, Sacral Nerve Stimulation, and Injectable Bulking Agents for Treatment of Fecal Incontinence

  Whitehead, W., Rao, S., Lowry, A., Gantz, M. & Bharucha, A. E.

  National Institutes of Health

  6/20/16 → 5/31/18

  Project: Research project

  • Fecal Incontinence
  • Injections
  • dextranomer
  • Safety
  • Electric Stimulation

• Measles virus airway epithelium entry, and rapid cell-to-cell spread

  Cattaneo, R. & Sinn, P.

  National Institute of Allergy and Infectious Diseases

  6/7/16 → 5/31/18

  Project: Research project

  • Measles virus
  • Epithelium
  • Viruses
  • Myeloid Cells
  • Virus Diseases

• First in-human PET imaging studies of NIS reporter [18F]BF4

  DeGrado, T. R.

  National Cancer Institute

  6/1/16 → 5/31/19

  Project: Research project

  • sodium-iodide symporter
  • Radiometry
  • Single-Photon Emission-Computed Tomography
  • Measles virus
  • Sodium Pertechnetate Tc 99m

• Development of Intrasaccular Flow Disrupters for Small and Ruptured Aneurysms

  Patterson, W. R. & Kallmes, D. F.

  National Institute of Neurological Disorders and Stroke

  6/1/16 → 5/31/18

  Project: Research project

  • Ruptured Aneurysm
  • Equipment and Supplies
  • Aneurysm
  • Catheters
  • United Arab Emirates

• Precision Medicine Initiative Cohort Program Biobank

  Cicek, M., Cicek, M. & Thibodeau, S. N.

  NIH Office of the Director

  6/1/16 → 5/31/21

  Project: Research project

  • precision medicine
  • disaster recovery
  • management information systems
  • information management
  • processing quality

• Immune Contribution to Brain Atrophy

  Johnson, A. J.

  National Institutes of Health

  6/1/16 → 5/31/18

  Project: Research project

  • Atrophy
  • Brain
  • T-Lymphocytes
  • Transgenic Mice
  • Neuroaid

• Disappearance of rifampin resistance in MRSA foreign body osteomyelitis

  Patel, R.

  National Institute of Allergy and Infectious Diseases

  6/1/16 → 5/31/18

  Project: Research project

  • osteomyelitis
  • foreign bodies
  • rifampicin
  • bacteria
  • infection

• Mechanisms Regulating Human NK Cell Cytotoxicity

  Billadeau, D. D.

  National Institute of Allergy and Infectious Diseases

  5/17/16 → 4/30/21

  Project: Research project

  • Cytokinesis
  • Natural Killer Cells
  • Septins
  • Microtubule-Organizing Center
  • Actins

• Clinical Implementation of Clopidogrel Pharmacogenetics: The TAILOR-PCI Trial - DCC

  Bailey, K. R.

  National Heart, Lung, and Blood Institute

  5/15/16 → 3/31/20

  Project: Research project

  • Cytochrome P-450 CYP2C19
  • Clopidogrel
  • Pharmacogenetics
  • Percutaneous Coronary Intervention
  • Alleles

• Assessment of hyperphosphorylated tau PET binding in primary progressive aphasia

  Josephs, K. A.

  National Institute of Neurological Disorders and Stroke

  5/15/16 → 4/30/18

  Project: Research project

  • Primary Progressive Aphasia
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
  • Positron-Emission Tomography
  • Neuroimaging
  • Language

• Postdoctoral Training Program for Research on Aging

  Conover, C. A.

  National Institute on Aging

  5/1/16 → 4/30/18

  Project: Research project

  • Mentors
  • Organized Financing
  • Biomedical Research
  • Education
  • Interdisciplinary Research

• Investigate the role of TPD52-AMPK pathway in tumorigenesis and cancer therapy

  Wang, L. M.

  National Institutes of Health

  4/15/16 → 2/28/21

  Project: Research project

  • Carcinogenesis
  • Breast Neoplasms
  • Metformin
  • Neoplasms
  • Energy Metabolism

• Matrix remodeling in microfluidic co-culture

  Tschumperlin, D. J.

  National Heart, Lung, and Blood Institute

  4/11/16 → 3/31/18

  Project: Research project

  • Microfluidics
  • Coculture Techniques
  • Extracellular Matrix
  • Cell Communication
  • Lung

• Endothelial function of amyloid precursor protein

  Katusic, Z. S.

  National Heart, Lung, and Blood Institute

  4/11/16 → 2/29/20

  Project: Research project

  • Amyloid beta-Protein Precursor
  • Endothelium
  • Cerebrovascular Circulation
  • Endothelial Cells
  • Blood Vessels

• Behavioral and Psychological Impact of Returning Breast Density Results to Latinas

  Vachon, C. M.

  National Institute on Minority Health and Health Disparities

  4/8/16 → 11/30/20

  Project: Research project

  • cancer
  • notifications
  • Underinsured
  • legislation
  • applicant

• Mechanisms of alpha-synuclein accumulation in traumatic brain injury (R21 NS094908 Resubmission)

  McLean, P. J.

  National Institute of Neurological Disorders and Stroke

  4/1/16 → 3/31/18

  Project: Research project

  • alpha-Synuclein
  • Traumatic Brain Injury
  • Adenosine Triphosphate
  • Parkinson Disease
  • Brain Injuries

• In Vivo Cell Tracking with PET

  DeGrado, T. R.

  National Heart, Lung, and Blood Institute

  4/1/16 → 3/31/18

  Project: Research project

  • Cell Tracking
  • Mesenchymal Stem Cells
  • sodium-iodide symporter
  • Iodides
  • Half-Life

• Shared decision making for stroke prevention in atrial fibrillation (SDM4Afib)

  Montori, V. M.

  National Heart, Lung, and Blood Institute

  4/1/16 → 3/31/21

  Project: Research project

  • Atrial Fibrillation
  • Decision Making
  • Stroke
  • Anticoagulants
  • Patient Compliance

• Functions of human and mouse Trem2 in vivo

  Fryer, J. D.

  4/1/16 → 3/31/18

  Project: Research project

• Regulation of hepatic lipid accumulation and insulin resistance

  Liu, J. D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/16 → 3/31/20

  Project: Research project

  • insulin resistance
  • fatty liver
  • liver
  • triacylglycerol lipase
  • lipids

• Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal study

  Whitwell, J. L.

  National Institute on Aging

  4/1/16 → 3/31/21

  Project: Research project

  • Molecular Imaging
  • Longitudinal Studies
  • Alzheimer Disease
  • Atrophy
  • Wernicke Aphasia

• Novel SCD1 inhibitors for treatment of cancer

  Copland, J. A. I., Hazlehurst, L. & Copland, J. A. I.

  National Institutes of Health, National Cancer Institute

  3/5/16 → 2/28/17

  Project: Research project

  • Stearoyl-CoA Desaturase
  • Neoplasms
  • Therapeutics
  • Lipogenesis
  • Fatty Acids

• Regulation of Vps4 during ESCRT function

  Katzmann, D. J.

  National Institute of General Medical Sciences

  3/1/16 → 11/30/19

  Project: Research project

  • Endosomal Sorting Complexes Required for Transport
  • Multivesicular Bodies
  • Ubiquitin
  • Cytokinesis
  • ubiquitin isopeptidase

• Catheter guided endovascular electric field ablation for thrombosis therapy.

  Oklu, R.

  National Institute of Biomedical Imaging and Bioengineering

  3/1/16 → 1/31/18

  Project: Research project

  • Catheters
  • Thrombosis
  • Electrodes
  • Varicose Ulcer
  • Venous Insufficiency

• TROY HTS Compound Screening

  Tran, N.

  National Institute of Neurological Disorders and Stroke

  2/15/16 → 1/31/19

  Project: Research project

  • Glioblastoma
  • Small Molecule Libraries
  • Proof of Concept Study
  • Structure-Activity Relationship
  • Blood-Brain Barrier

• A Phase II Evaluation of SABR in Oligometastatic Castration-Refractory Prostate Cancer and Immunogenicity of SABR

  Park, S., Park, S. S. & Dong, H. M.

  National Cancer Institute

  2/9/16 → 1/31/19

  Project: Research project

  • Castration
  • Prostatic Neoplasms
  • Radiotherapy
  • Choline
  • Immunity

• Organelle Dysfunction in Liver Inflammation

  Malhi, H. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/15/16 → 12/31/17

  Project: Research project

  • Inositol
  • Extracellular Vesicles
  • Organelles
  • Liver Diseases
  • Inflammation

• Multi-parameter Nonlinear Elasticity Mapping of Breast Masses

  Alizad, A. & Fatemi, M.

  National Cancer Institute

  1/8/16 → 11/30/20

  Project: Research project

  • breast
  • elastic properties
  • anxiety
  • pathology
  • cancer

• Pathogenesis of age-related Fuchs Endothelial Corneal Dystrophy

  Fautsch, M. P., Gottesfeld, J. M. & Gottesfeld, J. M.

  National Eye Institute

  1/1/16 → 12/31/19

  Project: Research project

  • Fuchs' Endothelial Dystrophy
  • Trinucleotide Repeat Expansion
  • Transcription Factor 4
  • RNA
  • Corneal Transplantation