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• Tuning Mitotic Kinesins Through Motor Domain Post Translational Modifications

  Rosenfeld, S.

  National Institute of General Medical Sciences

  Project: Research project

  • Kinesin 100%
  • Post Translational Protein Processing 71%
  • Mechanics 15%
  • Mitosis 14%
  • Microtubules 14%

• Mentored Clinical Scientist Research Career Development (K08) research grant

  Ibrahim, S. H.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Organized Financing 100%
  • Hepatocytes 92%
  • Ligands 77%
  • Liver 56%
  • Non-alcoholic Fatty Liver Disease 42%

• Brain Neurotropic Growth Factor Delivery to Prevent and Treat Alzheimer?s Disease

  Kanekiyo, T.

  National Institute on Aging

  Project: Research project

  • Liposomes 100%
  • Cell-Penetrating Peptides 97%
  • Transferrin 75%
  • Intercellular Signaling Peptides and Proteins 59%
  • Brain 43%

• Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology Project

  LeBrasseur, N. K., St. Sauver, J., Olson, J. E., Olson, J. E. & St. Sauver, J.

  National Institute on Aging

  Project: Research project

  • Electronic Health Records 100%
  • Epidemiology 61%
  • National Institute on Aging (U.S.) 52%
  • Geriatrics 46%
  • Biomarkers 31%

• Factors Influencing Access and Utilization of Genetic Prenatal Care Services Among Women from Underserved Populations

  Allyse, M.

  National Human Genome Research Institute

  Project: Research project

  • utilization 100%
  • genetic services 48%
  • health 41%
  • national minority 26%
  • diagnostic services 24%

• 2nd-Generation Spinal Analgesic Resiniferatoxin

  Beutler, A. S.

  Project: Research project

  • SBE4-beta-cyclodextrin 100%
  • Intractable Pain 71%
  • Freeze Drying 70%
  • Polysorbates 68%
  • Marketing 60%

• 3q26 Amplified Genes as Cooperative Oncogenic Drivers of Lung Squamous Cell Carcinoma

  Justilien, V.

  National Cancer Institute

  Project: Research project

  • Squamous Cell Carcinoma 100%
  • Lung 76%
  • Genes 41%
  • Stem Cells 37%
  • Epithelial Cells 18%

• Noninvasive detection of NASH by magnetic resonance elastography (MRE)

  Allen, A.

  Project: Research project

  • Non-alcoholic Fatty Liver Disease 100%
  • Elasticity Imaging Techniques 29%
  • Statistical Models 16%
  • Bariatric Surgery 16%
  • Biopsy 14%

• Tissue Engineered Tendon Complex for Rotator Cuff Repair and Regeneration

  Zhao, C. D.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Project: Research project

  • tendons 100%
  • bones 52%
  • tissues 27%
  • biocompatible materials 19%
  • tissue engineering 10%

• Microfabrication Tools for In Vitro Monitoring of Cancer Cell Metabolism

  Revzin, A. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Pharmacological Metabolism 100%
  • neoplasm cells 59%
  • Glucose 58%
  • Energy 56%
  • energy metabolism 52%

• Development of molecular assays for non-invasive bladder cancer detection

  Goodison, S.

  Project: Research project

  • Urinary Bladder Neoplasms 100%
  • Urinalysis 22%
  • Nucleic Acids 18%
  • Urinary Bladder Diseases 14%
  • Neoplasms 12%

• Translation of a Clinical Molecular Diagnostic Assay for Bladder Cancer

  Goodison, S.

  Project: Research project

  • Urinary Bladder Neoplasms 100%
  • Urinary Bladder Diseases 17%
  • Technology 15%
  • Neoplasms 14%
  • Cystoscopy 14%

• Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genome

  Lazaridis, K. N.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Exposome 100%
  • Sclerosing Cholangitis 87%
  • Genome 34%
  • Metabolome 22%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 21%

• Credentialing a Genetically Engineered Clinically-Relevant Mouse Model of Multiple Myeloma

  Chesi, M.

  National Cancer Institute

  Project: Research project

  • Credentialing 100%
  • Multiple Myeloma 91%
  • Transgenic Mice 50%
  • pomalidomide 46%
  • Lenalidomide 37%

• TrAstuzumab Cardiomyopathy Therapeutic Intervention with Carvedilol (TACTIC) Trial

  Herrmann, J. & Ruddy, K. J.

  National Cancer Institute

  Project: Research project

  • Carvedilol 100%
  • Trastuzumab 91%
  • Cardiomyopathies 62%
  • Cardiotoxicity 45%
  • Stroke Volume 36%

• Regulation of Necroptosis and inflammation

  Lou, Z.

  National Cancer Institute

  Project: Research project

  • Necroptosis 100%
  • Inflammation 36%
  • AMP-Activated Protein Kinases 27%
  • Neoplasms 12%
  • Gene Deletion 12%

• (PQD1) Clonal heterogeneity and targeted therapy resistance in melanoma

  Sekulic, A. D. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • Melanoma 100%
  • Neoplasms 42%
  • Therapeutics 20%
  • Informatics 15%
  • Dreams 14%

• 12th Meeting of the International Shoulder Group

  Morrow, M. (. M.

  Project: Research project

  • Shoulder 100%
  • Research Personnel 34%
  • Congresses 19%
  • Biomechanical Phenomena 19%
  • Interdisciplinary Research 13%

• Noninvasive Measurement of Potassium for Patients with Cardiac and Renal Disease

  Friedman, P. A.

  Project: Research project

  • Potassium 100%
  • Electrocardiography 36%
  • Dialysis 18%
  • Preliminary Data 11%
  • Heart Diseases 8%

• 2/3 Chromatin regulation during brain development and in ASD

  Abyzov, A.

  National Institute of Mental Health

  Project: Research project

  • Autism Spectrum Disorder 100%
  • Chromatin 67%
  • Organoids 66%
  • Brain 33%
  • Mutation 23%

• Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteins

  Li, H.

  National Institute on Aging

  Project: Research project

  • Microtubule-Associated Proteins 100%
  • RNA-Binding Proteins 97%
  • Alzheimer Disease 44%
  • Lenses 43%
  • Tauopathies 31%

• The contribution of RAD51C and RAD51D to breast and ovarian cancer

  Weroha, S. (., Couch, F. J. & Weroha, S. (.

  National Cancer Institute

  Project: Research project

  • Ovarian Neoplasms 100%
  • Breast Neoplasms 71%
  • Mutation 55%
  • Neoplasms 31%
  • Germ-Line Mutation 24%

• IRF4 and immunity to influenza infection

  Sun, J.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Cytotoxic T-Lymphocytes 100%
  • Human Influenza 94%
  • Immunity 67%
  • Cellular Immunity 59%
  • Humoral Immunity 48%

• Biomarker Discovery and Validation in Parkinson's Disease

  Pandey, A.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Biomarkers 70%
  • Substantia Nigra 53%
  • Cerebrospinal Fluid 50%
  • Proteomics 22%
  • Proteins 12%

• Mechanistic insights into the link between the A152T risk variant and tauopathy

  Cook, C.

  National Institute on Aging

  Project: Research project

  • Tauopathies 100%
  • Phosphorylation 35%
  • Transcriptome 31%
  • Brain 25%
  • Progressive Supranuclear Palsy 22%

• Administrative Core

  Boeve, B. F., Kantarci, K. M. & Rademakers, R. V.

  National Institute on Aging

  Project: Research project

  • Frontotemporal Lobar Degeneration 100%
  • Frontotemporal Dementia 16%
  • Dementia 15%
  • Patient Advocacy 9%
  • National Institute of Neurological Disorders and Stroke (U.S.) 7%

• Quantitative Assessment of Dynamic Joint Instabilities Using 4D CT Imaging

  McCollough, C. H., Zhao, K. D., Kinney, L. & Kinney, L.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Project: Research project

  • Imaging techniques 100%
  • Bone 51%
  • Computerized tomography 43%
  • Dosimetry 21%
  • Motion analysis 20%

• Phase I Trial with Two HER-2 B Cell Epitope Vaccine in Patients with Solid Tumors

  Bekaii-Saab, T., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • B-Lymphocyte Epitopes 100%
  • Vaccines 53%
  • Neoplasms 33%
  • Immune System 26%
  • Combined Vaccines 22%

• Development of tools for site-directed analysis of gene function

  Clark, K. J.

  NIH Office of the Director

  Project: Research project

  • Inflammasomes 100%
  • alleles 95%
  • Danio rerio 85%
  • Microglia 84%
  • Zebrafish 56%

• Therapeutic implication of CD38 in CLL

  Chanan Khan, A. A. & Chini, E. N.

  National Cancer Institute

  Project: Research project

  • T-Lymphocytes 100%
  • B-Lymphocytes 93%
  • daratumumab 68%
  • Neoplasms 65%
  • Study Guides 57%

• The glial mechanism for electrical brain stimulation

  Worrell, G. A. & Wu, L.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Extracellular Vesicles 100%
  • Deep Brain Stimulation 65%
  • Neuroglia 43%
  • Astrocytes 26%
  • Electric Stimulation 25%

• Mitochondrial injury interferes with endogenous renal repair in experimental renovascular disease

  Eirin, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Kidney 100%
  • Wounds and Injuries 81%
  • Acute Kidney Injury 63%
  • Renal Artery Obstruction 50%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 43%

• Imaging mitochondrial function of progenitor cells transplanted to the ischemic myocardium

  Rodriguez-Porcel, M. G.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • stem cells 100%
  • myocardium 99%
  • image analysis 74%
  • therapeutics 19%
  • reporter genes 16%

• Extracellular alpha-synuclein in Parkinson's Disease

  McLean, P. J., Kinney, L. & Kinney, L.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • alpha-Synuclein 100%
  • Macroautophagy 12%
  • Disease Progression 9%
  • Lewy Bodies 5%
  • Neurons 5%

• Utility of memantine in preventing cognitive dysfunction in children receiving cranial radiotherapy

  Laack, N. N.

  National Cancer Institute

  Project: Research project

  • Memantine 100%
  • Cognitive Dysfunction 41%
  • Radiotherapy 36%
  • Child 20%
  • Cognition 17%

• Optimization of Tumor Vaccines for the Aged

  Gendler, S. J., Kinney, L., Kinney, L. & Kinney, L.

  National Cancer Institute

  Project: Research project

  • cancer vaccines 100%
  • dendritic cells 55%
  • neoplasms 41%
  • T-lymphocytes 32%
  • immune response 29%

• Novel Informatics Approaches for Ascertainment of PAD Status and Adverse Outcomes

  Arruda-Olson, A. M.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • Informatics 100%
  • Epidemiology 25%
  • Electronic medical equipment 23%
  • Genomics 18%
  • Display devices 13%

• Identification of small molecule modulators of mitochondrial creatine kinase 1

  Hitosugi, T. D.

  National Cancer Institute

  Project: Research project

  • Mitochondrial Form Creatine Kinase 100%
  • Phosphocreatine 34%
  • Trastuzumab 22%
  • Neoplasms 21%
  • phosphocyclocreatine 20%

• Secondary use of EMR for residency training in asthma care and documentation

  Sohn, S.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Electronic Health Records 100%
  • Documentation 99%
  • Asthma 98%
  • Internship and Residency 94%
  • Clinical Competence 40%

• Pediatric Eye Disease Investigator Group Network

  Holmes, J. M.

  Project: Research project

  • Eye Diseases 100%
  • Pediatrics 89%
  • Amblyopia 80%
  • Strabismus 61%
  • Research Personnel 59%

• Neuroprotective Treatment Trial Planning in REM Sleep Behavior Disorder

  Boeve, B. F.

  National Institute on Aging

  Project: Research project

  • REM Sleep Behavior Disorder 100%
  • Synucleinopathies 84%
  • Clinical Trials 24%
  • Multiple System Atrophy 19%
  • Biomarkers 9%

• The Contribution of Age-Related Tauopathies to Alzheimer's Disease

  Dickson, D. W.

  National Institute on Aging

  Project: Research project

  • Tauopathies 100%
  • Alzheimer Disease 44%
  • Chronic Traumatic Encephalopathy 39%
  • Neuropathology 13%
  • Cognitive Dysfunction 13%

• Pathologic Role of Inflammation and Mechanistic Analysis of Myofibroblastogenesis in Arthrofibrosis

  Abdel, M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Project: Research project

  • Myofibroblasts 100%
  • Inflammation 58%
  • Joints 46%
  • Disease Progression 34%
  • Primary Cell Culture 26%

• MECHANISMS OF APOPTOSIS IN CHOLANGIOCYTES

  Que, F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Apoptosis 100%
  • Ions 40%
  • Peptide Hydrolases 27%
  • Caspase 1 20%
  • Immune System Diseases 17%

• PHARMACOGENOMICS OF ACAMPROSATE TREATMENT OUTCOME

  Biernacka, J. M., Karpyak, V. M. & Karpyak, V. M.

  National Institute on Alcohol Abuse and Alcoholism

  Project: Research project

  • Acamprosate 100%
  • Pharmacogenetics 55%
  • Alcoholism 55%
  • Placebos 24%
  • Pharmacogenomic Testing 23%

• Enabling Comparative Effectiveness Research in Silent Brain Infarction Through Natural Language Processing and Big Data

  Liu, H. D.

  Project: Research project

  • Brain Infarction 100%
  • Stroke 26%
  • Natural Language Processing 25%
  • Comparative Effectiveness Research 19%
  • Leukoencephalopathies 17%

• Peri-electrode large molecule microdialysis of the brain during induced seizures in mice, pigs, and humans with epilepsy undergoing resective surgery

  Howe, C. L. & Worrell, G. A.

  National Institute of Neurological Disorders and Stroke

  Project: Research project

  • Epilepsy 100%
  • Microdialysis 99%
  • Seizures 92%
  • Electrodes 76%
  • Swine 62%

• A Clinical Study of Latiglutenase as a Treatment for Symptom Reduction for Celiac Disease

  Murray, J. A. & Murray, J. A.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • ALV003 100%
  • Celiac Disease 73%
  • Gluten-Free Diet 48%
  • Clinical Studies 24%
  • Glutens 13%

• Impact of APOE3 and APOE4 on the peripheral immune system in Alzheimer's disease

  Fryer, J. D., Kang, S. & Kang, S.

  National Institute on Aging

  Project: Research project

  • Apolipoproteins E 100%
  • Protein Isoforms 86%
  • Central Nervous System 79%
  • Alzheimer Disease 69%
  • Human ApoE protein 65%

• Modeling granuloma formation using engineered microcapsules

  Revzin, A.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Granuloma 100%
  • Capsules 62%
  • Leprosy 30%
  • Macrophages 28%
  • Communicable Diseases 22%