Treatment of choice for advanced disease is 5-FU, however response rate to this therapy is low. Recent reports detail increased cytotoxicity against a human colorectal carcinoma cell line with combined 5-FU & AZT. This trial of AZT & 5-FU will assess concomitant administration of these agents, & fully detail the metabolic & pharmacokinetic profile of AZT before evaluating combined AZT & 5-FU.
|Effective start/end date||10/1/91 → 9/30/95|
- National Center for Research Resources
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